Oxidative Stress in Cancer Biology and Therapy

  • Douglas R. Spitz
  • Kenneth J. Dornfeld
  • Koyamangalath Krishnan
  • David Gius

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Oxidative Stress and Tumor Response (Preclinical)

    1. Front Matter
      Pages 1-1
    2. Iman M. Ahmad, Maher Y. Abdalla
      Pages 3-19
    3. Andrean L. Simons, Kevin P. Orcutt, Joshua M. Madsen, Peter M. Scarbrough, Douglas R. Spitz
      Pages 21-46
    4. Melissa A. Fath, Andrean L. Simons, Jeffrey Erickson, Mark E. Anderson, Douglas R. Spitz
      Pages 47-58
    5. Melissa L. Teoh-Fitzgerald, Frederick E. Domann
      Pages 59-84
  3. Oxidative Stress in Normal Tissue Response (Preclinical)

    1. Front Matter
      Pages 95-95
    2. Paiboon Jungsuwadee, Mary Vore, Daret K. St. Clair
      Pages 97-129
    3. Ruth K. Globus, Vincent Caiozzo, Munjal Acharya, John R. Fike, Charles Limoli
      Pages 169-192
  4. Imaging Redox Changes and Therapeutic Response (Preclinical and Clinical)

    1. Front Matter
      Pages 193-193
  5. Oxidative Stress in Tumor Response (Clinical)

    1. Front Matter
      Pages 217-217
    2. Heather C. Hatcher, Frank M. Torti, Suzy V. Torti
      Pages 233-256
    3. Joseph J. Cullen
      Pages 257-275
    4. Kevin L. Du, Jarod C. Finlay, Timothy C. Zhu, Theresa M. Busch
      Pages 277-300
    5. Weihua Shan, Weixiong Zhong, Jamie Swanlund, Terry D. Oberley
      Pages 301-331
    6. William L. Stone, Sharon E. Campbell, Koyamangalath Krishnan
      Pages 333-354
  6. Oxidative Stress in Normal Tissue Response (Clinical)

    1. Front Matter
      Pages 355-355
    2. Giovanni Mantovani, Clelia Madeddu, Antonio Macciò
      Pages 373-385
    3. Joel S. Greenberger, Valerian E. Cagan, James Peterson, Michael W. Epperly
      Pages 387-406
    4. Neife Ap. Guinaim dos Santos, Antonio Cardozo dos Santos
      Pages 407-425
    5. William C. Zamboni, Ninh M. La-Beck
      Pages 427-452
  7. Back Matter
    Pages 453-460

About this book


During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs.


The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.


Basic Cancer Clinical Oxidative Practice Research Stress Studies Study

Editors and affiliations

  • Douglas R. Spitz
    • 1
  • Kenneth J. Dornfeld
    • 2
  • Koyamangalath Krishnan
    • 3
  • David Gius
    • 4
  1. 1.Free Radical & Radiation Biology, Graduate ProgramUniversity of IowaIowa CityUSA
  2. 2.Duluth Clinic, Radiation OncologyUniversity of MinnesotaDuluthUSA
  3. 3.James H. Quillen College of Medicine, Internal MedicineEast Tennessee State UniversityJohnson CityUSA
  4. 4.Radiation Oncology, Cancer Biology and PediatricsVanderbilt Medical SchoolNashvilleUSA

Bibliographic information