© 2012

Diabetes & C-Peptide

Scientific and Clinical Aspects

  • Anders A.F. Sima

Part of the Contemporary Diabetes book series (CDI)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Donald F. Steiner
    Pages 1-5
  3. Charlotte Nerelius, Emma Lindahl, Michael Landreh, Hans Jörnvall
    Pages 7-16
  4. Thomas Forst, Matthias M. Weber, Thomas Kunt, Andreas Pfützner
    Pages 45-54
  5. Lina Nordquist, Åsa Kallas, Sara Stridh, Fredrik Palm, John Wahren
    Pages 67-77
  6. Hideki Kamiya, Wei-Xian Zhang, Anders A. F. Sima
    Pages 79-92
  7. Anders A. F. Sima, Wei-Xian Zhang
    Pages 93-109
  8. Jaime Haidet, Vincenza Cifarelli, Xuehui Geng, Massimo Trucco, Patrizia Luppi
    Pages 111-127
  9. Karen E. Porter, Romana S. Mughal
    Pages 129-144
  10. Daniel Walcher, Nikolaus Marx
    Pages 153-160
  11. Anders A. F. Sima
    Pages 161-163
  12. Back Matter
    Pages 165-169

About this book


In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide’s physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.

Editors and affiliations

  • Anders A.F. Sima
    • 1
  1. 1.Departments of Pathology and NeurologyWayne State UniversityDetroitUSA

Bibliographic information

  • Book Title Diabetes & C-Peptide
  • Book Subtitle Scientific and Clinical Aspects
  • Editors Anders A.F. Sima
  • Series Title Contemporary Diabetes
  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-61779-390-5
  • Softcover ISBN 978-1-4939-5957-0
  • eBook ISBN 978-1-61779-391-2
  • Edition Number 1
  • Number of Pages XIII, 169
  • Number of Illustrations 28 b/w illustrations, 35 illustrations in colour
  • Topics Endocrinology
    Internal Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


From the reviews:

“The authors of this volume show in 14 chapters that C-peptide considered and inactive part of proinsulin has a series of metabolic roles. An interesting text. For diabetologists.” (Pediatric Endocrinology Reviews (PER), Vol. 9 (3), March, 2012)