Signal Transduction Protocols

  • Louis M. Luttrell
  • Stephen S. G. Ferguson

Part of the Methods in Molecular Biology book series (MIMB, volume 756)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Overviews

    1. Front Matter
      Pages 1-1
    2. Kuljeet Kaur, Jason M. Kehrl, Raelene A. Charbeneau, Richard R. Neubig
      Pages 75-98
    3. Stuart Maudsley, Wayne Chadwick, Liyun Wang, Yu Zhou, Bronwen Martin, Sung-Soo Park
      Pages 99-130
  3. Receptor–Ligand Interactions

    1. Front Matter
      Pages 131-131
  4. Receptor–Receptor Interactions

    1. Front Matter
      Pages 165-165
    2. Lamia Achour, Maud Kamal, Ralf Jockers, Stefano Marullo
      Pages 183-200
    3. Laëtitia Comps-Agrar, Damien Maurel, Philippe Rondard, Jean-Philippe Pin, Eric Trinquet, Laurent Prézeau
      Pages 201-214
    4. Christophe Altier, Gerald W. Zamponi
      Pages 215-225
  5. Receptor–Effector Coupling

    1. Front Matter
      Pages 227-227
    2. Thomas R. Hynes, Evan A. Yost, Stacy M. Yost, Catherine H. Berlot
      Pages 229-243
    3. Darlaine Pétrin, Mélanie Robitaille, Terence E. Hébert
      Pages 245-261
    4. Brock F. Binkowski, Frank Fan, Keith V. Wood
      Pages 263-271
  6. Spatial Control of Signal Transduction

  7. Protein–Protein Interactions

    1. Front Matter
      Pages 343-343
    2. Stefanie L. Ritter, Randy A. Hall
      Pages 345-356
    3. Syed M. Ahmed, Avais M. Daulat, Stéphane Angers
      Pages 357-370
    4. Benjamin Aguila, May Simaan, Stéphane A. Laporte
      Pages 371-380
    5. Shupeng Li, Sheng Chen, Yu Tian Wang, Fang Liu
      Pages 381-393
    6. Stephen W. Michnick, Po Hien Ear, Christian Landry, Mohan K. Malleshaiah, Vincent Messier
      Pages 395-425
  8. Back Matter
    Pages 427-430

About this book


It is increasingly clear that signal transduction is a highly organized and integrated process.  Divided into two convenient sections, Signal Transduction Protocols, Third Edition focuses on experimental approaches to better understand the complexity of signal transduction.  Introductory chapters provide perspective on several of the challenges involved in signal transduction research and offer guidance on selecting the best approaches to various types of questions.  The individual chapters provide detailed experimental protocols covering various topics, from the effects of ligand binding on receptor conformation and effector coupling, to moving inside the cell in order to capture the spatial and temporal characteristics of signaling events. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.


Authoritative and accessible, Signal Transduction Protocols serves as an ideal guide to scientists of all backgrounds and is a valuable resource for future progress in the field of signal transduction research.


G protein-coupled receptor cellular systems analysis protein-protein interactions receptor endocytosis receptor trafficking receptor-effector coupling receptor-ligand interactions receptor-receptor interactions

Editors and affiliations

  • Louis M. Luttrell
    • 1
  • Stephen S. G. Ferguson
    • 2
  1. 1.Div. Endocrinology, Metabolism &, Medical GeneticsMedical University of South CarolinaCharlestonUSA
  2. 2.Dept. Physiology & PharmacologyUniversity of Western OntarioLondonCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-159-8
  • Online ISBN 978-1-61779-160-4
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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