Animal Models of Schizophrenia and Related Disorders

  • Patricio O'Donnell

Part of the Neuromethods book series (NM, volume 59)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Gwenaëlle Le Pen, Alfredo Bellon, Marie-Odile Krebs, Thérèse M. Jay
    Pages 25-77
  3. Andrea Schmitt, Peter Gebicke-Haerter, Ulrich Sommer, Markus Heck, Anja Lex, Mario Herrera-Marschitz et al.
    Pages 93-111
  4. Darryl W. Eyles, Thomas H.J. Burne, Suzy Alexander, Xiaoying Cui, John J. McGrath
    Pages 113-125
  5. Pascal Steullet, Jan-Harry Cabungcal, Anita Kulak, Michel Cuenod, Françoise Schenk, Kim Q. Do
    Pages 149-188
  6. P. Alexander Arguello, Joseph A. Gogos
    Pages 189-209
  7. Yavuz Ayhan, Hanna Jaaro-Peled, Akira Sawa, Mikhail V. Pletnikov
    Pages 211-229
  8. Juan E. Belforte, Kazu Nakazawa
    Pages 231-242
  9. Patricia Tueting, Erminio Costa, Alessandro Guidotti
    Pages 243-260
  10. Yisheng Lu, Dong-Min Yin, Wen-Cheng Xiong, Lin Mei
    Pages 261-277
  11. Back Matter
    Pages 279-290

About this book


Animal models of schizophrenia and other major psychiatric disorders have been sought for decades, and, as a result, we are now facing new vistas on pathophysiology that could lead to novel therapeutic approaches and even hint at possible preventive strategies. Animal Models of Schizophrenia and Related Disorders presents an overview of the information that can be obtained with several different models and a detailed account of how to generate such models in order to ensure that the manipulations used to model schizophrenia-relevant phenomena are used consistently across laboratories.  This detailed volume features pharmacological models such as non-competing NMDA antagonists, emphasizing their use in vitro, neurodevelopmental models such as the neonatal ventral hippocampal lesion and the antimitotic MAM, models that reproduce environmental factors such as neonatal hypoxia, vitamin D deficits, and prenatal immune activation, as well as several different genetic model approaches.  As a volume in the Neuromethods series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results.


Practical and cutting-edge, Animal Models of Schizophrenia and Related Disorders highlights the successes in the use of animal models to gain insight on pathophysiological mechanisms of relevance to major psychiatric disorders in the hope of inspiring investigators to expand the research and test targets that could restore or ameliorate function.


Cortical inhibitory interneurons Environmental factors Gene variants Neurology Novel therapeutics Pathophysiology Psychiatric disorders

Editors and affiliations

  • Patricio O'Donnell
    • 1
  1. 1.School of Medicine, Depts. of Anatomy & NeurobiologyUniversity of MarylandBaltimoreUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-156-7
  • Online ISBN 978-1-61779-157-4
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site
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