© 2011

Experimental and Applied Immunotherapy

  • Jeffrey Medin
  • Daniel Fowler

Table of contents

  1. Front Matter
    Pages i-xvii
  2. T Cell Therapy: State-of-the-Art

    1. Front Matter
      Pages 1-1
  3. Non-T Cell Therapeutic Approaches

    1. Front Matter
      Pages 35-35
    2. David Spaner, Angela Bahlo
      Pages 37-57
    3. Christoph Rader
      Pages 59-83
    4. Yoko Kosaka, Armand Keating
      Pages 85-105
    5. Elizabeth Scheid, Michael Ricci, Ronan Foley
      Pages 107-126
    6. Moïra François, Jacques Galipeau
      Pages 127-148
  4. T Cell Therapeutic Approaches

    1. Front Matter
      Pages 149-149
    2. Brad H. Nelson, John R. Webb
      Pages 151-172
    3. Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Réjean Lapointe
      Pages 173-194
    4. Adele Y. Wang, Megan K. Levings
      Pages 207-228
    5. Wolfgang Zimmermann, Robert Kammerer
      Pages 229-249
  5. Non-Cellular Aspects of Cancer Immunotherapy

    1. Front Matter
      Pages 279-279
    2. Megan Nelles, Vincenzo Salerno, Yixin Xu, Christopher J. Paige
      Pages 281-305
    3. Natalie Grinshtein, Jonathan Bramson
      Pages 323-338

About this book


Immunotherapy is now recognized as an essential component of treatment for a wide variety of cancers. It is an interdisciplinary field that is critically dependent upon an improved understanding of a vast network of cross-regulatory cellular populations and a diversity of molecular effectors; it is a leading example of translational medicine with a favorable concept-to-clinical-trial timeframe of just a few years. There are many established immunotherapies already in existence, but there are exciting new cancer immunotherapies just on the horizon, which are likely to be more potent, less toxic and more cost effective than many therapies currently in use. Experimental and Applied Immunotherapy is a state-of-the-art text offering a roadmap leading to the creation of these future cancer-fighting immunotherapies. It includes essays by leading researchers that cover a wide variety of topics including T cell and non-T cell therapy, monoclonal antibody therapy, dendritic cell-based cancer vaccines, mesenchymal stromal cells, negative regulators in cancer immunology and immunotherapy, non-cellular aspects of cancer immunotherapy, the combining of cancer vaccines with conventional therapies, the combining of oncolytic viruses with cancer immunotherapy, transplantation, and more. The field of immunotherapy holds great promise that will soon come to fruition if creative investigators can bridge seemingly disparate disciplines, such as T cell therapy, gene therapy, and transplantation therapy. This text is a vital tool in the building of that bridge.


Cancer Immunotherapy translational immunotherapy

Editors and affiliations

  • Jeffrey Medin
    • 1
  • Daniel Fowler
    • 2
  1. 1.University Health NetworkUniversity of TorontoTorontoCanada
  2. 2.National Cancer Institute, Experimental Transplatation &National Institutes of HealthBethesdaUSA

Bibliographic information

  • Book Title Experimental and Applied Immunotherapy
  • Editors Jeffrey Medin
    Daniel Fowler
  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-60761-979-6
  • Softcover ISBN 978-1-62703-822-5
  • eBook ISBN 978-1-60761-980-2
  • Edition Number 1
  • Number of Pages XVII, 442
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Immunology
    Cell Biology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


From the reviews:

“The text is divided into five parts, each comprising of one or more chapters written by word-renowned scientists in the field. … the editors have made an excellent effort to incorporate most relevant topics on immunotherapy in this textbook, and most chapters have been well written with supporting diagrams and tables. The text provides researchers in the field with up-to-date concepts and detailed current and future strategies for cancer immunotherapy.” (Ali Roghanian, Immunology News, May, 2012)

“Cancer immunotherapy is a vast area of research and it is covered in some depth by this very informative book. Each of the 19 chapters consists of a quick introduction to the specific area of interest of one of the contributors followed by in-depth analysis of experimental techniques currently being used successfully, or otherwise, in the field. … Overall, an enlightening book that covers a variety of immunotherapy techniques, but the book is directed specifically at those interested in cancer treatment.” (Donal Wall, Microbiology Today, November, 2011)

“A highly informative compendium of essays with a heavy focus on cancer immunotherapy. … the essays are excellent and present the state of the art of many emerging and established immunotherapies for cancer. … Immunisation approaches are considered by several authors. … I can recommend this excellent collection of succinct essays that span the breath of ongoing research in cancer immunotherapy.” (British Journal of Clinical Pharmacology, May, 2011)