Animal Models of Dementia

  • Peter Paul De Deyn
  • Debby Van Dam

Part of the Neuromethods book series (NM, volume 48)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Animal Modeling: General and Ethical Aspects and Drug Discovery Pipeline

    1. Front Matter
      Pages 1-1
    2. Peter Paul De Deyn, Debby Van Dam
      Pages 3-13
    3. I. Anna S. Olsson, Peter Sandøe
      Pages 15-33
    4. Debby Van Dam, Peter Paul De Deyn
      Pages 35-49
  3. Methodological Considerations when Developing Animal Models of Dementia

    1. Front Matter
      Pages 51-51
    2. Annemie Van Dijck, Debby Van Dam, Peter Paul De Deyn
      Pages 53-75
    3. Susan L. Stoddard, James A. Rogers III
      Pages 91-96
  4. Validation of Animal Models of Dementia

    1. Front Matter
      Pages 97-97
    2. Daniel Pirici, Christine Van Broeckhoven, Samir Kumar-Singh
      Pages 99-141
    3. Debby Van Dam, Annemie Van Dijck, Peter Paul De Deyn
      Pages 143-154
    4. Giancarlo Pepeu, Maria Cristina Rosi
      Pages 169-185
    5. Greet Vanhoutte, Adriaan Campo, Annemie Van der Linden
      Pages 187-220
  5. Animal Models of Alzheimer’s Disease

    1. Front Matter
      Pages 221-221
    2. Maria E. Giannakou, Damian C. Crowther
      Pages 223-240
    3. Tjakko J. Van Ham, Ellen A. A. Nollen
      Pages 241-253
    4. Rob Willemsen, Sandra van’t Padje, John C. van Swieten, Ben A. Oostra
      Pages 255-269
    5. Adolfo Toledano, Maria Isabel Álvarez
      Pages 295-345
    6. Patricia A. Lawlor, Deborah Young
      Pages 347-370
    7. Jacob M. Basak, David M. Holtzman
      Pages 371-385
    8. Robert M. J. Deacon
      Pages 387-398
    9. Debby Van Dam, Peter Paul De Deyn
      Pages 399-413
    10. Yuji Yoshiike, Akihiko Takashima
      Pages 415-437
    11. Patrick M. Sullivan
      Pages 439-447
    12. Nicolas Sergeant, Luc Buée
      Pages 449-468
    13. Michael Sy, Masashi Kitazawa, Frank LaFerla
      Pages 469-482
  6. Animal Models of Non-Alzheimer Neurodegenerative Disease

    1. Front Matter
      Pages 483-483
    2. Sheila M. Fleming, J. David Jentsch, Marie-FranÇoise Chesselet
      Pages 485-492
    3. Patrick Aubourg, Caroline Sevin, Nathalie Cartier
      Pages 493-513
    4. Ludo Van Den Bosch
      Pages 515-531
    5. Hana N. Dawson, Daniel T. Laskowitz
      Pages 533-547
  7. Animal Models of Vascular Dementia

    1. Front Matter
      Pages 549-549
    2. Karl J. Fryxell
      Pages 551-576
  8. Animal Models of Normal Pressure Hydrocephalus

    1. Front Matter
      Pages 613-613
    2. Petra M. Klinge
      Pages 615-640
  9. Animal Models of Traumatic Dementia

    1. Front Matter
      Pages 641-641
    2. Jennifer E. Slemmer, Mohammad Z. Hossain, John T. Weber
      Pages 643-662
  10. Animal Models of Toxic Dementia

    1. Front Matter
      Pages 663-663
    2. Angela Maria Ribeiro, Silvia R. Castanheira Pereira
      Pages 665-683
    3. Luigi F. Rodella
      Pages 685-726
  11. Back Matter
    Pages 727-732

About this book


With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.


Alzheimer’s disease Brain diseases Cognitive impairment Drug discovery and development Neurodegeneration Neurological disorders New therapeutic targets Preclinical research Vascular dementia

Editors and affiliations

  • Peter Paul De Deyn
    • 1
  • Debby Van Dam
    • 2
  1. 1.Institute Born-Bunge, Lab of Neurochemistry & BehaviourUniversity of AntwerpWilrijkBelgium
  2. 2.Institute Born-Bunge, Lab of Neurochemistry & BehaviourUniversity of AntwerpWilrijkBelgium

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-897-3
  • Online ISBN 978-1-60761-898-0
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site
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