MAP Kinase Signaling Protocols

Second Edition

  • Rony Seger

Part of the Methods in Molecular Biology book series (MIMB, volume 661)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Activation and Function of Components of the MAP Kinase Signaling Cascades

    1. Front Matter
      Pages 1-1
    2. Deborah N. Chadee, John M. Kyriakis
      Pages 59-73
    3. Huamin Zhou, Jianming Chen, Jiahuai Han
      Pages 75-89
    4. Kazuhiro Nakamura, Gary L. Johnson
      Pages 91-106
    5. Kimberly Burkhard, Paul Shapiro
      Pages 107-122
  3. Study of MAP Kinase Cascades as Transmitters of Membranal Receptor Signals

    1. Front Matter
      Pages 123-123
    2. Mario Chiariello, Jose P. Vaqué, Piero Crespo, J. Silvio Gutkind
      Pages 137-150
    3. Colin D. White, David B. Sacks
      Pages 151-165
    4. Michelle C. Mendoza, Ekrem Emrah Er, John Blenis
      Pages 185-203
    5. Marzia Indrigo, Alessandro Papale, Daniel Orellana, Riccardo Brambilla
      Pages 205-220
  4. Structure-Function Relationships and Localization of MAP Kinases

    1. Front Matter
      Pages 221-221
    2. Elizabeth J. Goldsmith, Xiaoshan Min, Haixia He, Tianjun Zhou
      Pages 223-237
    3. Kevin M. Sours, Natalie G. Ahn
      Pages 239-255
    4. Arif Jivan, Aarati Ranganathan, Melanie H. Cobb
      Pages 273-285
    5. Matilde Marchi, Riccardo Parra, Mario Costa, Gian Michele Ratto
      Pages 287-301
  5. Studies on the Regulation of MAP Kinase Cascades

    1. Front Matter
      Pages 303-303
    2. Céline Tárrega, Caroline Nunes-Xavier, Rocío Cejudo-Marín, Jorge Martín-Pérez, Rafael Pulido
      Pages 305-321
    3. Melissa M. McKay, Deborah K. Morrison
      Pages 323-334
    4. Adán Pinto, Piero Crespo
      Pages 335-342
    5. Shen-Hsi Yang, Andrew D. Sharrocks
      Pages 343-367
    6. David Gilbert, Monika Heiner, Rainer Breitling, Richard Orton
      Pages 369-384
  6. Use of Lower Organisms, Animal Models, and Human Genetics in the Study of MAP Kinases

    1. Front Matter
      Pages 385-385
    2. Elaine A. Elion, Rupam Sahoo
      Pages 387-399
    3. Gergana Galabova-Kovacs, Manuela Baccarini
      Pages 421-431
    4. William E. Tidyman, Katherine A. Rauen
      Pages 433-447
  7. Study of MAP Kinases in Specific Physiological Systems

    1. Front Matter
      Pages 449-449
    2. Khadija Essafi-Benkhadir, Jacques Pouysségur, Gilles Pagès
      Pages 451-469
    3. Hongbo Chi, Richard A. Flavell
      Pages 471-480
    4. Bettina Wagner, Maria Sibilia
      Pages 481-495
    5. Eva M. Eves, Marsha Rich Rosner
      Pages 497-505
    6. Christopher J. Caunt, Stephen P. Armstrong, Craig A. McArdle
      Pages 507-524
  8. Back Matter
    Pages 525-529

About this book


Mitogen-activated protein (MAP) kinase (MAPK) cascades are key signaling components that govern essentially all cellular processes evoked by any type of stimulation, and it has been well established that the malfunctioning of these cascades leads to various diseases including cancer, autoimmunity, and diabetes. In MAP Kinase Signaling Protocols, Second Edition, expert researchers fully update the popular first edition the key techniques used in the study of MAPK signaling cascades in various cellular contexts. This thorough volume explores essential topics such as activation and function of components of the MAPK signaling cascades, the study of MAPK cascades as transmitters of membranal receptor signals, structure-function relationships of MAPKs, studies on the regulation of MAPK cascades, the use of lower organisms, animal models, and human genetics in the study of MAPKs, as well as the study of MAPKs in specific systems and diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters includes introductions to their respective subjects, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, MAP Kinase Signaling Protocols, Second Edition aims to facilitate the study of MAPKs and allow for quicker progress in our knowledge of many vital cellular processes as well as devastating diseases.


Activation Cancer and inflammation Cell signaling Endoplasmatisches Reticulum Enzymatic activity Growth factors Immune System Immunity MAPK Migration Protein-protein interactions Regulation Subcellular localization Vivo cellular processes

Editors and affiliations

  • Rony Seger
    • 1
  1. 1.Dept. Biological RegulationWeizmann Institute of ScienceRehovotIsrael

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-794-5
  • Online ISBN 978-1-60761-795-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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