Targeted Therapies

Mechanisms of Resistance

  • Daniel Gioeli

Part of the Molecular and Translational Medicine book series (MOLEMED)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Jason R. Neil, Forest M. White
    Pages 55-75
  3. Julia D. Wulfkuhle, Menawar Khalil, Joseph C. Watson, Lance A. Liotta, Emanuel F. Petricoin III
    Pages 77-94
  4. Sudhir Chowbina, Kevin A. Janes, Shayn M. Peirce, Jason A. Papin
    Pages 113-126
  5. Benjamin Kefas, Benjamin W. Purow
    Pages 155-170
  6. Back Matter
    Pages 197-201

About this book


This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. 

Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Editors and affiliations

  • Daniel Gioeli
    • 1
  1. 1.Health System, Deptartment of Microbiology and Cancer CUniversity of VirginiaCharlottesvilleUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-60761-477-7
  • Online ISBN 978-1-60761-478-4
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology