Transgenic and Mutant Tools to Model Brain Disorders

  • Allan V. Kalueff
  • Carisa L. Bergner

Part of the Neuromethods book series (NM, volume 44)

Table of contents

  1. Front Matter
    Pages ii-xiv
  2. General Approaches

    1. Front Matter
      Pages 1-1
    2. Carisa L. Bergner, Rupert J. Egan, Peter C. Hart, Jonathan M. Cachat, Peter R. Canavello, Allan V. Kalueff
      Pages 3-12
    3. Mareike Müller, Jocelien Olivier, Judith Homberg
      Pages 13-31
    4. Gui-Lan Ye, Kevin B. Baker, Sara M. Mason, Wandong Zhang, Laura Kirkpatrick, Thomas H. Lanthorn et al.
      Pages 65-90
    5. Robert Lalonde, Catherine Strazielle
      Pages 91-112
  3. Specific Brain Disorders

    1. Front Matter
      Pages 138-138
    2. Amanda N. Smolinsky, Carisa L. Bergner, Peter C. Hart, Rupert J. Egan, Brett D. Dufour, Justin L. LaPorte et al.
      Pages 139-149
    3. Rupert J. Egan, Carisa L. Bergner, Peter C. Hart, Justin L. LaPorte, Allan V. Kalueff
      Pages 179-189
    4. Peter R. Canavello, Rupert J. Egan, Carisa L. Bergner, Peter C. Hart, Jonathan M. Cachat, Allan V. Kalueff
      Pages 191-200
    5. Lieve Desbonnet, Katsunori Tomiyama, Noriaki Koshikawa, Colm M. P. O’Tuathaigh, John L. Waddington
      Pages 217-239
  4. Back Matter
    Pages 241-246

About this book


As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders.  In Transgenic and Mutant Tools to Model Brain Disorders, leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research.  Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia.  As a volume in the successful Neuromethods™ series, the chapters provide authoritative reviews covering the most commonly used approaches in the field.

Cutting-edge and concise, Transgenic and Mutant Tools to Model Brain Disorders offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.


Biological psychiatry Genetic diseases Genetically modified animal models Human brain Knockout mice Pathogenesis behavior psychiatry

Editors and affiliations

  • Allan V. Kalueff
    • 1
  • Carisa L. Bergner
    • 2
  1. 1.School of MedicineTulane UniversityNew OrleansU.S.A.
  2. 2.MilwaukeeU.S.A.

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2010
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-473-9
  • Online ISBN 978-1-60761-474-6
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals