Multi-Drug Resistance in Cancer

  • Jun Zhou

Part of the Methods in Molecular Biology book series (MIMB, volume 596)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Bruce C. Baguley
    Pages 1-14
  3. Wouter B. Nagengast, Thijs H. Oude Munnink, Eli C. F. Dijkers, Geke A. P. Hospers, Adrienne H. Brouwers, Carolien P. Schröder et al.
    Pages 15-31
  4. Sven Rottenberg, Marina Pajic, Jos Jonkers
    Pages 33-45
  5. Jean-Pierre Gillet, Michael M. Gottesman
    Pages 47-76
  6. Adorjan Aszalos, Barbara J. Taylor
    Pages 123-139
  7. Frantisek Staud, Martina Ceckova, Stanislav Micuda, Petr Pavek
    Pages 199-222
  8. Douglas D. Ross, Takeo Nakanishi
    Pages 251-290
  9. Jeannie M. Padowski, Gary M. Pollack
    Pages 359-384
  10. Emily Crowley, Christopher A. McDevitt, Richard Callaghan
    Pages 405-432
  11. Hamid Morjani, Claudie Madoulet
    Pages 433-446
  12. Alexandra Stege, Andrea Krühn, Hermann Lage
    Pages 447-465
  13. Xing-Jie Liang, Chunying Chen, Yuliang Zhao, Paul C. Wang
    Pages 467-488
  14. Back Matter
    Pages 489-492

About this book


With the devastating complication of cancer cells becoming simultaneously resistant to many structurally and mechanistically unrelated drugs, the efficacy of chemotherapeutic management of cancer often becomes severely limited. In Multi-Drug Resistance in Cancer, leading researchers in the field provide comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance protein, to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The extensive volume also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression, as well as techniques for detection and imaging of drug transporters, methods for investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and cutting-edge, Multi-Drug Resistance in Cancer offers a state-of-art collection of reviews and methods for both basic and clinician investigators who are interested in the vital study of cancer multi-drug resistance mechanisms and reversal strategies.


ATP-binding Cancer stem cells Chemotherapy Drug transporter function P-glycoproteins Regulation Resistance reversal agents tissue

Editors and affiliations

  • Jun Zhou
    • 1
  1. 1.College of Life SciencesNankai UniversityTianjinChina, People's Republic

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2010
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-415-9
  • Online ISBN 978-1-60761-416-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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Oncology & Hematology