© 2009

Thiamine Deficiency and Associated Clinical Disorders


Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. David W. McCandless
    Pages 1-7
  3. David W. McCandless
    Pages 9-16
  4. David W. McCandless
    Pages 17-30
  5. David W. McCandless
    Pages 31-46
  6. David W. McCandless
    Pages 47-64
  7. David W. McCandless
    Pages 81-101
  8. David W. McCandless
    Pages 103-112
  9. David W. McCandless
    Pages 113-129
  10. David W. McCandless
    Pages 131-143
  11. David W. McCandless
    Pages 145-149
  12. David W. McCandless
    Pages 151-160
  13. Back Matter
    Pages 185-192

About this book


The past twenty years have seen remarkable advances in neuroscience, neurology, imaging techniques, and diagnostic strategies. These advances have been successfully applied to many different diseases, including thiamine deficiency and associated clinical disorders. Syndromes such as beriberi, Wernicke’s disease, Leigh’s disease, African Seasonal Ataxia, and various inherited ataxias, have all benefited from improved scientific approaches.

Thiamine Deficiency and Associated Clinical Disorders represents an intriguing area of both basic and clinical investigation. Modern imaging and diagnostic strategies have facilitated the rapid treatment, and potential reversal of these clinical disorders. The fusion of laboratory and clinical knowledge serve as an example of how research can translate to successful treatment. This book is designed to bring together cogent results from both basic and clinical investigation. These data will be of interest to neurologists, internists, nutritionists, biochemists, neurochemists, neuroscientists, and many others with interest in thiamine deficiency.

About the Author:

Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 25th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others.


African Seasonal Ataxia Central Pontine Myelinolysis Leigh's disease Neurology Nutrition Thiamin Wernicke's disease beri-beri

Authors and affiliations

  1. 1.Rosalind Franklin Univ. of Med. & Sci.The Chicago Medical School atNo. ChicagoU.S.A.

Bibliographic information

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From the reviews:

“This short 192 page book Thiamine Deficiency and Associated Clinical Disorders, which is part of the ongoing Contemporary Clinical Neuroscience series, is authored by David McCandless, Ph.D. who is known for his work in metabolic encephalopathy. For those who wish to have a deeper understanding of a number of metabolic derangements which result in neurological dysfunction, this book would be of interest. For the neuroradiologist there is an opportunity to view gross pathology and histopathology … .” (American Journal of Neuroradiology, October, 2009)