© 2009

Checkpoint Controls and Targets in Cancer Therapy

  • Zahid H. Siddik
  • Brings together experts, who are defining the field of checkpoints, and as such represents a unique collection of insightful contributions that will serve as an important resource for both the research community and the medical oncologists

  • Since checkpoint regulation is critical in understanding cancer development and cancer therapy, the interest will be diverse and appeal to both basic and translational investigators alike


Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Circuitry of Checkpoint Response

    1. Front Matter
      Pages 1-1
    2. Krijn K. Dijkstra, Cristophe Blanchetot, Johannes Boonstra
      Pages 3-26
    3. Paula J. Hurley, Fred Bunz
      Pages 27-36
    4. Alwin Krämer
      Pages 53-67
    5. Mong-Hong Lee, Sai-Ching Jim Yeung, Heng-Yin Yang
      Pages 69-80
  3. Checkpoint Response and the Aetiology of Cancer

  4. Targeting Checkpoint Response in Cancer Therapy

    1. Front Matter
      Pages 170-170
    2. Sean M. Post, Alfonso Quintás-Cardama, Guillermina Lozano
      Pages 171-188
    3. Xiao-Feng Le, Robert C. Bast Jr
      Pages 215-233
    4. Paolo Pevarello, James R. Bischoff, Ciro Mercurio
      Pages 235-244
    5. Haiying Zhang, Zhan Xiao, Tom Sowin
      Pages 245-259

About this book



There is no question that loss of cell cycle checkpoint regulation is an intrinsic characteristic of cancer. However, many tumors retain parallel checkpoint pathways that are activated by antitumor agents and facilitate therapeutic response. Failures in these therapy-linked checkpoint controls are closely associated with cancers that are highly resistant to therapeutic interventions. Checkpoint Controls and Targets in Cancer provides present-day mechanistic understandings of how multiple sets of proteins orchestrate cell cycle progression, discusses critical checkpoint controls that are evaded for cancer development, focuses on checkpoint pathways associated with antitumor effects, and identifies specific checkpoint regulators for targeting with small molecules in the clinical management of cancer. These aspects of cell cycle checkpoints are articulated critically by renowned experts from both academia and industry, and new concepts are forwarded that challenge existing dogmas. Collectively, Checkpoint Controls and Targets in Cancer provides a unique collection of insightful contributions, which are timely and offer significant interest and appeal to basic, translational and clinical scientists.


BRCA DNA cancer cancer research cancer therapy cell cell death leukemia lymphoma ovarian cancer research resistance tumor

Editors and affiliations

  • Zahid H. Siddik
    • 1
  1. 1.M.D. Anderson Cancer CenterUniversity of TexasHoustonU.S.A.

Bibliographic information

  • Book Title Checkpoint Controls and Targets in Cancer Therapy
  • Editors Zahid H. Siddik
  • Series Title Cancer Drug Discovery and Development
  • Series Abbreviated Title Cancer Drug Discovery,Development
  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-60761-177-6
  • Softcover ISBN 978-1-61779-635-7
  • eBook ISBN 978-1-60761-178-3
  • Edition Number 1
  • Number of Pages XIV, 274
  • Number of Illustrations 30 b/w illustrations, 13 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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From the reviews: “This nicely organized book focuses on cell cycle checkpoint and cancer biology/therapeutics. … The book is written for graduate students, residents, and postdoctoral investigators in basic, translational, or clinical cancer research. The contributing authors are active investigators at the forefront of this field. … This book presents timely, comprehensive reviews of the rapidly progressing field of checkpoint. It should be quite useful for readers who are seeking a solid grasp of updated information in this field.” (Hiroaki Kiyokawa, Doody’s Review Service, March, 2010)