Checkpoint Controls and Targets in Cancer Therapy

  • Zahid H. Siddik

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Circuitry of Checkpoint Response

    1. Front Matter
      Pages 1-1
    2. Krijn K. Dijkstra, Cristophe Blanchetot, Johannes Boonstra
      Pages 3-26
    3. Paula J. Hurley, Fred Bunz
      Pages 27-36
    4. Alwin Krämer
      Pages 53-67
    5. Mong-Hong Lee, Sai-Ching Jim Yeung, Heng-Yin Yang
      Pages 69-80
  3. Checkpoint Response and the Aetiology of Cancer

  4. Targeting Checkpoint Response in Cancer Therapy

    1. Front Matter
      Pages 170-170
    2. Sean M. Post, Alfonso Quintás-Cardama, Guillermina Lozano
      Pages 171-188
    3. Xiao-Feng Le, Robert C. Bast Jr
      Pages 215-233
    4. Paolo Pevarello, James R. Bischoff, Ciro Mercurio
      Pages 235-244
    5. Haiying Zhang, Zhan Xiao, Tom Sowin
      Pages 245-259
    6. Johannes Rudolph
      Pages 261-269
  5. Back Matter
    Pages 271-273

About this book



There is no question that loss of cell cycle checkpoint regulation is an intrinsic characteristic of cancer. However, many tumors retain parallel checkpoint pathways that are activated by antitumor agents and facilitate therapeutic response. Failures in these therapy-linked checkpoint controls are closely associated with cancers that are highly resistant to therapeutic interventions. Checkpoint Controls and Targets in Cancer provides present-day mechanistic understandings of how multiple sets of proteins orchestrate cell cycle progression, discusses critical checkpoint controls that are evaded for cancer development, focuses on checkpoint pathways associated with antitumor effects, and identifies specific checkpoint regulators for targeting with small molecules in the clinical management of cancer. These aspects of cell cycle checkpoints are articulated critically by renowned experts from both academia and industry, and new concepts are forwarded that challenge existing dogmas. Collectively, Checkpoint Controls and Targets in Cancer provides a unique collection of insightful contributions, which are timely and offer significant interest and appeal to basic, translational and clinical scientists.


BRCA DNA cancer cancer research cancer therapy cell cell death leukemia lymphoma ovarian cancer research resistance tumor

Editors and affiliations

  • Zahid H. Siddik
    • 1
  1. 1.M.D. Anderson Cancer CenterUniversity of TexasHoustonU.S.A.

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-60761-177-6
  • Online ISBN 978-1-60761-178-3
  • Buy this book on publisher's site
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