© 2010

Heart Failure

Bench to Bedside


Part of the Contemporary Cardiology book series (CONCARD)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Clinical, Physiology and Genetics Changes in Heart Failure

    1. Front Matter
      Pages 1-1
    2. José Marín-García
      Pages 3-13
    3. José Marín-García
      Pages 23-42
  3. Biochemical and Molecular Changes in Heart Failure

    1. Front Matter
      Pages 44-44
  4. The Mitochondrial Organelle and the Heart

    1. Front Matter
      Pages 72-72
  5. Experimental Models of Heart Failure

    1. Front Matter
      Pages 108-108
    2. José Marín-García
      Pages 109-127
  6. Signaling, Stress and Cellular Changes in Heart Failure

  7. Peripheral Changes and Co-morbid Conditions in Heart Failure

    1. Front Matter
      Pages 234-234
    2. José Marín-García
      Pages 257-270

About this book


Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease.  An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies.

Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF.  Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. Heart Failure: Bench to Bedside thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers.

Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.


Bioenergetics Cardiac Drug Therapy Cell Biology Gene Therapy Genetics Heart Failure Left Ventricular Assist Device Molecualr Medicine Molecular Biology cardiac function cardiovascular

Authors and affiliations

  1. 1.Neuromuscular InstituteMolecular Cardiology &Highland ParkUSA

Bibliographic information

  • Book Title Heart Failure
  • Book Subtitle Bench to Bedside
  • Authors José Marín-García
  • Series Title Contemporary Cardiology
  • Series Abbreviated Title Contemporary Cardiology
  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-60761-146-2
  • Softcover ISBN 978-1-61779-693-7
  • eBook ISBN 978-1-60761-147-9
  • Edition Number 1
  • Number of Pages XI, 470
  • Number of Illustrations 14 b/w illustrations, 71 illustrations in colour
  • Topics Cardiology
    Internal Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


From the reviews:

“A clear and comprehensive review is desperately needed to lessen the time readers spend searching the Internet or rummaging through massive numbers of clinical trials. … the text still can appeal to any health science student, physician-in-training, practicing physician, and of course, cardiologist. In fact, this text is strongly recommended for cardiologists pursuing additional training in cardiac transplantation and care of advanced heart failure. … This book will serve as a useful reference and could become a powerful tool for cardiology … .” (Joseph Sam Owen, Journal of the American Medical Association, February, 2011)

“This book tackles a broad array of topics in heart failure in an organized manner. … most useful to specialists in heart failure, especially those with an interest in molecular and cell biology research, or those interested in translating basic science research into clinical investigations. The book will be of interest to cardiologists in training as well as adult and pediatric cardiologists. … It is unique as it adds gene expression and how it may play a role in the heart failure disease process.” (Joaquin Crespo, Doody’s Review Service, September, 2010)