Mouse Models for Drug Discovery

Methods and Protocols

  • Gabriele Proetzel
  • Michael V. Wiles

Part of the Methods in Molecular Biology book series (MIMB, volume 602)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Michael V. Wiles, Rob A. Taft
    Pages 23-36
  3. Rosalba Sacca, Sandra J. Engle, Wenning Qin, Jeffrey L. Stock, John D. McNeish
    Pages 37-54
  4. Frank Koentgen, Gabriele Suess, Dieter Naf
    Pages 55-77
  5. Gianpaolo Rando, Andrea Biserni, Paolo Ciana, Adriana Maggi
    Pages 79-92
  6. Derry C. Roopenian, Gregory J. Christianson, Thomas J. Sproule
    Pages 93-104
  7. Steve Pino, Michael A. Brehm, Laurence Covassin-Barberis, Marie King, Bruce Gott, Thomas H. Chase et al.
    Pages 105-117
  8. Philip N. Howles
    Pages 157-179
  9. Lisette Bevaart, Margriet J. Vervoordeldonk, Paul P. Tak
    Pages 181-192
  10. John P. Sundberg, Kathleen A. Silva, Caroline McPhee, Lloyd E. King JR
    Pages 193-213
  11. James E. Talmadge
    Pages 215-233
  12. Cong Peng, Shaoguang Li
    Pages 253-266
  13. Carisa L. Bergner, Amanda N. Smolinsky, Peter C. Hart, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte et al.
    Pages 267-282
  14. Peter C. Hart, Carisa L. Bergner, Amanda N. Smolinsky, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte et al.
    Pages 299-321
  15. Robert W. Burgess, Gregory A. Cox, Kevin L. Seburn
    Pages 347-393
  16. Eva Medina
    Pages 405-410
  17. Derry C. Roopenian, Gregory J. Christianson, Thomas J. Sproule
    Pages E1-E2
  18. Back Matter
    Pages 417-421

About this book


As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies.  In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.


Disease topics Experimental design Genetically engineered Genomes Inbred and outbred mice Laboratory Target identification Toxicological studies infectious disease

Editors and affiliations

  • Gabriele Proetzel
    • 1
  • Michael V. Wiles
    • 2
  1. 1.The Jackson LaboratoryBar HarborUSA
  2. 2.Jackson LaboratoryBar HarborUSA

Bibliographic information

  • DOI
  • Copyright Information Humana Press, a part of Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60761-057-1
  • Online ISBN 978-1-60761-058-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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