Telomeres and Telomerase in Cancer

  • Keiko Hiyama

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Basic Background

    1. Keiko Hiyama, Eiso Hiyama, Jerry W. Shay
      Pages 3-21
    2. Nadya Dimitrova
      Pages 23-46
    3. Amy N. Depcrynski, Patrick C. Sachs, Lynne W. Elmore, Shawn E. Holt
      Pages 47-85
    4. Malissa C. Diehl, Lynne W. Elmore, Shawn E. Holt
      Pages 87-125
    5. Hilda A. Pickett, Roger R. Reddel
      Pages 127-148
  3. Telomeres and Telomerase in Human Cancers

    1. Keiko Hiyama, Eiso Hiyama, Keiji Tanimoto, Masahiko Nishiyama
      Pages 171-180
    2. Eiso Hiyama, Keiko Hiyama
      Pages 181-210
    3. H. Ohyashiki Junko, Ohyashiki Kazuma
      Pages 211-224
    4. Brittney-Shea Herbert, Erin M. Goldblatt
      Pages 225-249
    5. Chandanamali Punchihewa, Danzhou Yang
      Pages 251-280
  4. Experimental Protocols

    1. Akira Shimamoto, Eriko Aoki, Angie M. Sera, Hidetoshi Tahara
      Pages 337-350
    2. Wei-Qin Jiang, Jeremy D. Henson, A. Neumann Axel, R. Reddel Roger
      Pages 351-364
  5. Back Matter
    Pages 365-373

About this book


Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. "Telomeres and Telomerase in Cancers", edited by Keiko Hiyama, focuses on "Human" telomeres and telomerase, from basic biology and hypothesis in human normal cells and cancer cells to clinical application as diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.


DNA DNA Damage Hematopoietic Malignancies Lengthening of Telomeres Telomerase Inhibitors biology cancer cancer research cell enzyme genes mortality protein research stem cell

Editors and affiliations

  • Keiko Hiyama
    • 1
  1. 1.Dept. Translational Cancer ResearchHiroshima UniversityHiroshimaJapan

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-60327-306-0
  • Online ISBN 978-1-60327-879-9
  • Buy this book on publisher's site
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