Metal Carcinogenesis Testing

Principles and in Vitro Methods

  • Max Costa

Part of the Biological Methods book series (BM)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Metal-Induced Cancer in Humans and Experimental Animals

  3. Mechanisms of Metal Carcinogenesis

  4. Principles and Methods of In Vitro Metal Carcinogensis Testing

  5. Back Matter
    Pages 1-4

About this book


Metal Carcinogenesis Testing explains fundamental principles of metal carcinogenesis as they are currently understood, and provides detailed practical descriptions of rapid and inexpensive in vitro assay methodology presently in use for the detection of potentially carci­ nogenic metals and their compounds. Mounting experimental evidence has suggested that a number of metals and their compounds are potentially carcinogenic to humans. Since humans are exposed to these potentially carcinogenic metals in industrial situations and through environmental pollution, it is essential that experimental protocols be available to identify the specific metal compounds that are potentially carcinogenic. This book affords a thorough description of the various carcinogenesis test systems available for metals, centering on those that are rapid, inexpensive, and most reliable. The principles are discussed at the level of human exposure, of animal studies, and of research in vitro. Additionally, the molecular mechanisms of metal-induced cancer are considered at each ofthese three levels.In large part, the emphasis rests on the use of in vitro, biochemical and bacterial studies, including tissue culture, because these methods are the basis of the rapid and inexpensive screening of potentially carcinogenic substances.


cancer carcinogenesis cell cell culture research screening tissue

Authors and affiliations

  • Max Costa
    • 1
  1. 1.University of Texas Medical School at Houston

Bibliographic information

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