Essentials of Apoptosis

A Guide for Basic and Clinical Research

  • Zheng Dong
  • Xiao-Ming Yin

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Part I. Molecules and Pathways of Apoptosis

    1. Front Matter
      Pages 1-1
    2. Stefan J. Riedl, Fiona L. Scott
      Pages 3-24
    3. Wen-Xing Ding, Xiao-Ming Yin
      Pages 25-61
    4. Eric C. LaCasse, Herman H. Cheung, Allison M. Hunter, Stephanie Plenchette, Douglas J. Mahoney, Robert G. Korneluk
      Pages 63-93
    5. Maria Eugenia Guicciardi, Gregory J. Gores
      Pages 119-150
    6. Silvia Campello, Luca Scorrano
      Pages 151-175
    7. Michael W. Harr, Clark W. Distelhorst
      Pages 177-197
    8. Han-Ming Shen, Shazib Pervaiz
      Pages 199-221
    9. Jonathan L. Coloff, Yuxing Zhao, Jeffrey C. Rathmell
      Pages 223-237
    10. Crissy Dudgeon, Wei Qiu, Quanhong Sun, Lin Zhang, Jian Yu
      Pages 239-260
    11. Carylyn J. Marek, Lars-Peter Erwig
      Pages 261-282
    12. Heinrich Huber, Eric Bullinger, Markus Rehm
      Pages 283-297
  3. Part II: Apoptosis in Model Organisms

    1. Front Matter
      Pages 299-299
    2. Naohide Watanabe, Eric Lam
      Pages 301-324
    3. Didac Carmona-Gutierrez, Frank Madeo
      Pages 325-354
    4. Monica Darland-Ransom, Yi-Chun Wu, Ding Xue
      Pages 355-373
    5. Dianne C. Purves, Jessica P. Monserrate, Carrie Baker Brachmann
      Pages 375-405
  4. Part III. Apoptosis in Mammalian Physiology and Pathogenesis

    1. Front Matter
      Pages 407-407
    2. Zahra Zakeri, Richard A. Lockshin
      Pages 409-422
    3. Christopher P. Dillon, Douglas R. Green
      Pages 423-442
    4. Emma C. Josefsson, Benjamin T. Kile
      Pages 443-459
    5. R. Anne Stetler, Armando P. Signore, Jun Chen
      Pages 461-478
    6. Qiuli Liang, Jianhua Zhang
      Pages 479-504
    7. Hamid el Azzouzi, Meriem Bourajjaj, Paula A. da Costa Martins, Leon J. De Windt
      Pages 505-521
    8. Stefan W. Ryter, Hong Pyo Kim, Augustine M. K. Choi
      Pages 523-545
    9. Yosuke Osawa, Ekihiro Seki, David A. Brenner
      Pages 547-564
    10. Navjotsingh Pabla, Qingqing Wei, Zheng Dong
      Pages 565-579
  5. Part IV. Alternative cell death mechanisms and pathways

    1. Front Matter
      Pages 597-597
    2. Linde Duprez, Nele Vanlangenakker, Nele Festjens, Franky Van Herreweghe, Tom Vanden Berghe, Peter Vandenabeele
      Pages 599-633
    3. Katsumi Kitagawa
      Pages 635-646
    4. Nathalie Andrieu-Abadie
      Pages 647-669
    5. Wentao Gao, Jeong-Han Kang, Yong Liao, Min Li, Xiao-Ming Yin
      Pages 671-688
  6. Part V. Approaches to the study of apoptosis

    1. Front Matter
      Pages 689-689
    2. Man Jiang, Craig Brooks, Guie Dong, Xiaoning Li, Hong-Min Ni, Xiao-Ming Yin et al.
      Pages 691-711
  7. Back Matter
    Pages 713-742

About this book


As a fundamental biological process, cell death and cell survival is essential to the normal homeostasis of the organism. Our knowledge on this process has been tremendously expanded in the past two decades. Essentials of Apoptosis: A Guide for Basic and Clinical Research was first published in 2003. It timely provided a comprehensive but concise summary of the essential information of apoptosis to both new investigators to the field and seasoned researchers seeking an integrated view of the topics. The past several years have witnessed significant new developments in the field of apoptosis and cell death in general. The concept of various types of cell death has been further developed. The studies in both basic and clinical disciplines have been greatly expanded. Notable progresses have been made in extending the work into the therapeutic arena. As a result, the field has matured considerably and developed extensive crosstalk with works in other fields. The second edition incorporates these new developments, in addition to the basic core concepts and machinery of apoptosis. Multiple new topics are added that expand the coverage on different types of cell death (apoptosis, necrosis, autophagic death and mitotic death), and on different death pathways (mediated by mitochondria, endoplasmic reticulum, death receptors, or lysosome). Furthermore, several integrated topics linking cell death to metabolism, redox status, transcription regulation are included and a systems biology approach to study apoptosis is introduced. Moreover, the roles of apoptosis and cell death in the pathogenesis of many human diseases in every major organ system are explored in details with novel therapeutic outlooks. This edition is the result of the hard work by more than 80 leading experts from across the world.

Authoritative, comprehensive and highly instructive, the second edition of Essentials of Apoptosis should be valuable for both novice and seasoned investigators, as an informative reference as well as a practical guide.


Activation Immune System Translation bioinformatics cells mammalian embryos metabolism molecular mechanisms physiology regulation saccharomyces cerevisiae transcription

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  • Zheng Dong
  • Xiao-Ming Yin

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