G Protein-Coupled Receptors in Drug Discovery

  • Wayne R. Leifert

Part of the Methods in Molecular Biology book series (MIMB, volume 552)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Richard M. Eglen, Terry Reisine
    Pages 1-13
  3. Maite de los Frailes, Emilio Diez
    Pages 15-37
  4. Christine Williams, Stephen J. Hill
    Pages 39-50
  5. Hanspeter Gubler
    Pages 79-95
  6. John Simms, Nathan E. Hall, Polo H.C. Lam, Laurence J. Miller, Arthur Christopoulos, Ruben Abagyan et al.
    Pages 97-113
  7. Amanda L. Aloia, Richard V. Glatz, Edward J. McMurchie, Wayne R. Leifert
    Pages 115-129
  8. Wayne R. Leifert, Olgatina Bucco, Mahinda Y. Abeywardena, Glen S. Patten
    Pages 131-141
  9. Tamara Cooper, Edward J. McMurchie, Wayne R. Leifert
    Pages 143-151
  10. Elizabeth A. Davenport, Parvathi Nuthulaganti, Robert S. Ames
    Pages 199-211
  11. Simon J. Dowell, Andrew J. Brown
    Pages 213-229
  12. Ye Fang, Joydeep Lahiri
    Pages 231-238
  13. Ye Fang, Ann M. Ferrie, Elizabeth Tran
    Pages 239-252
  14. Sébastien Granier, Samuel Kim, Juan José Fung, Michael P. Bokoch, Charles Parnot
    Pages 253-268
  15. Kasper B. Hansen, Hans Bräuner-Osborne
    Pages 269-278
  16. Kaleeckal G. Harikumar, Laurence J. Miller
    Pages 279-291
  17. Kasper B. Hansen, Hans Bräuner-Osborne
    Pages 343-357
  18. Back Matter
    Pages 373-376

About this book


The G protein-coupled receptors (GPCRs), known to be one of the largest superfamilies in the human genome, underpin a multitude of physiological processes and represent a significant target for bioactive and drug discovery programs. In G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, experts in the field provide a range of classic and cutting-edge laboratory protocols developed for GPCR research, as well as several current review articles relevant to the area of high throughput GPCR screening, with discussion on GPCR structure and GPCR signalling. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easy to use, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols serves to aid all those who wish to further the vital research in their GPCR drug discovery programs.


Calcium Cellular signalling Chemokine Drug development GPCRs Ligands physiology

Editors and affiliations

  • Wayne R. Leifert
    • 1
  1. 1.CSIRO Human NutritionAdelaideAustralia

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60327-316-9
  • Online ISBN 978-1-60327-317-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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