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Animal Models of Acute Neurological Injuries

  • Book
  • © 2009

Overview

Editors:
  1. Jun Chen

    1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, USA

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  2. Zao C. Xu

    1. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, USA

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  3. Xiao-Ming Xu

    1. Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, USA

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  4. John H. Zhang

    1. Department of Physiology and Pharmacology Department of Neurosurgery Department of Anesthesiology, Loma Linda University Medical School, Loma Linda, USA

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  • Forty established animal models for acute neurological injury
  • Special chapters on animal anesthesia, monitoring and tissue harvesting
  • Step-by-step manual on all aspects of technical issues related to animal modeling
  • Full color photographs on all key surgical steps
  • Written by experts in each field and by the original developers of the animal models

Part of the book series: Springer Protocols Handbooks (SPH)

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Table of contents (42 protocols)

  1. Cerebral Ischemic Animal Models

    1. Neonatal Hypoxia-Ischemia

      1. Model of Neonatal Focal Cerebral Ischemia-Reperfusion
        • Zinaida S. Vexler, Donna M. Ferriero
        Pages 247-255

  2. Cerebral Hemorrhage Animal Models

    1. Subarachnoid Hemorrhage

      1. Monofilament Perforation Subarachnoid Hemorrhage Rat Model
        • Julian Cahill, John H. Zhang
        Pages 261-270
      2. Blood Injection Subarachnoid Hemorrhage Rat Model
        • Hartmut Vatter, Erdem Gueresir, Volker Seifert
        Pages 271-278
      3. Filament Perforation Subarachnoid Hemorrhage: Mouse Model
        • Hideyuki Kamii, Teiji Tominaga
        Pages 279-286
      4. Blood Injection Subarachnoid Hemorrhage Mouse Model
        • Tarkan Calisaneller, Chih-Lung Lin, Naoya Ukita, Ryo Yoshimura, Yi Wang, Mark Fitzgerald et al.
        Pages 287-292

    2. Cerebral Vasospasm

      1. Blood Injection Cerebral Vasospasm Rabbit Model
        • Mario Zuccarello
        Pages 295-300
      2. Double Blood-Injection Cerebral Vasospasm Canine Model
        • Shigeru Nishizawa
        Pages 301-313
      3. Nonhuman Primate Blood-Clot Placement Cerebral Vasospasm Model
        • Ayako Kawashima, R. Loch Macdonald
        Pages 315-328

    3. Intracerebral Hemorrhage

      1. Blood Injection Intracerebral Hemorrhage Rat Model
        • Thomas O'Lynnger, Ya Hua, Guohua Xi
        Pages 331-336
      2. Bacterial Collagenase Injection Intracerebral Hemorrhage Rat Model
        • Mark Grossetete, Gary A. Rosenberg
        Pages 337-348
      3. Blood Injection Intracerebral Hemorrhage Mouse Model
        • Ludmila Belayev
        Pages 349-357
      4. Blood Injection Intracerebral Hemorrhage Pig Model
        • Ya Hua, Yuxiang Gu, Guohua Xi
        Pages 359-364

  3. Traumatic CNS Injury Animal Models

    1. Experimental Brain Injury Models

      1. Fluid Percussion Injury Model
        • Jonathan Lifshitz
        Pages 369-384
      2. Controlled Cortical Impact Injury Model
        • C. Edward Dixon, Anthony E. Kline
        Pages 385-391
      3. Marmarou Weight Drop Injury Model
        • Christina R. Marmarou, Ruth Prieto, Keisuke Taya, Harold F. Young, Anthony Marmarou
        Pages 393-407

    2. Experimental Spinal Cord Injury Models

      1. MASCIS Spinal Cord Contusion Model
        • Wise Young
        Pages 411-421
      2. Infinite Horizon Spinal Cord Contusion Model
        • Stephen Scheff, Kelly N. Roberts
        Pages 423-432
      3. The Ohio State University ESCID Spinal Cord Contusion Model
        • Lyn B. Jakeman, Dana M. McTigue, Patricia Walters, Bradford T. Stokes
        Pages 433-447
      4. Acute Clip Impact-Compression Model
        • Charles H. Tator, Peter Poon
        Pages 449-460
      5. Experimental Laceration Spinal Cord Injury Model
        • Yi Ping Zhang, Lisa B.E. Shields, Christopher B. Shields
        Pages 461-470
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Keywords

About this book

Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation.

Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.

Reviews

From the reviews:

"In this book, the editors have provided detailed discussions on numerous models of acute neurologic injury … . an invaluable resource to anyone starting out in the neuroinjury field or to experienced individuals who require an update in terms of animal modeling. … I recommend this book to … investigators in the field of neurologic injuries, including students, basic scientists, and clinicians. I think anyone in the field of experimental or clinical neurologic disorders will find this book to be extremely helpful … ." (American Journal of Neuroradiology, Vol. 30, March, 2009)

Editors and Affiliations

  • Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, USA

    Jun Chen

  • Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, USA

    Zao C. Xu

  • Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, USA

    Xiao-Ming Xu

  • Department of Physiology and Pharmacology Department of Neurosurgery Department of Anesthesiology, Loma Linda University Medical School, Loma Linda, USA

    John H. Zhang

Bibliographic Information

  • Book Title: Animal Models of Acute Neurological Injuries

  • Editors: Jun Chen, Zao C. Xu, Xiao-Ming Xu, John H. Zhang

  • Series Title: Springer Protocols Handbooks

  • DOI: https://doi.org/10.1007/978-1-60327-185-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media LLC 2009

  • Hardcover ISBN: 978-1-60327-184-4Published: 09 October 2008

  • Softcover ISBN: 978-1-61737-877-5Published: 20 January 2011

  • eBook ISBN: 978-1-60327-185-1Published: 16 December 2008

  • Series ISSN: 1949-2448

  • Series E-ISSN: 1949-2456

  • Edition Number: 1

  • Number of Pages: XXI, 498

  • Topics: Neurosciences, Neurology, Animal Models

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

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