© 2009

Animal Models of Acute Neurological Injuries

  • Jun Chen
  • Zao C. Xu
  • Xiao-Ming Xu
  • John H. Zhang

Part of the Springer Protocols Handbooks book series (SPH)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Animal Care and Surgery

    1. Laurel D. Schantz
      Pages 3-10
    2. Andrew R. Blickman, Lisa J. Brossia
      Pages 11-18
    3. Robert Ayer, Julian Cahill, Takashi Sugawara, Vikram Jadhav, John H. Zhang
      Pages 19-38
    4. Julian Cahill, John H. Zhang
      Pages 39-45
    5. Aaron H. Puckett, Christine D. Nunn, Stephen M. Onifer
      Pages 47-60
  3. Cerebral Ischemic Animal Models

    1. Global Cerebral Ischemic Models

      1. Ping Deng, Zao C. Xu
        Pages 65-76
      2. Clifton W. Callaway, Eric S. Logue
        Pages 87-101
      3. Mioara D. Manole, Robert W. Hickey, Henry L. Alexander, Robert S.B. Clark
        Pages 103-113
      4. Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Gab Seok Kim, Teiji Tominaga et al.
        Pages 115-125
    2. Focal Cerebral Ischemic Models

      1. Ying Mao, Wei Zhu, Guo-Yuan Yang
        Pages 129-139
      2. T. N. Lin, S. T. Chen, Y. Y. He, W. M. Cheung, C. Y. Hsu
        Pages 141-153
      3. Yoshihiro Murata, Xiaoying Wang, Eng H. Lo
        Pages 155-167
      4. David Kleinfeld, Beth Friedman, Patrick D. Lyden, Andy Y. Shih
        Pages 169-185
      5. Feng Zhang, Steven H. Graham, Jun Chen
        Pages 187-196
      6. Masaya Oda, Taku Sugawara, Kohei Kokubun, Kazuo Mizoi, Hiroyuki Kinouchi
        Pages 197-205
      7. Faisal Adhami, Chia-Yi Kuan
        Pages 207-217
    3. Neonatal Hypoxia-Ischemia

      1. Changlian Zhu, Xiaoyang Wang, Klas Blomgren
        Pages 221-230
      2. X. Ji, M. Derrick, S. Tan
        Pages 231-246

About this book


Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries.  Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues.  This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation.

Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.


Animal care and surgery CNS injury and disease Cerebral hemorrhage Cerebral ischemic animal models Cortex Nervous system forebrain

Editors and affiliations

  • Jun Chen
    • 1
  • Zao C. Xu
    • 2
  • Xiao-Ming Xu
    • 3
  • John H. Zhang
    • 4
  1. 1.Department of NeurologyUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Department of Anatomy and Cell BiologyIndiana University School of MedicineIndianapolisUSA
  3. 3.Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurological SurgeryIndiana University School of MedicineIndianapolisUSA
  4. 4.Department of Physiology and Pharmacology Department of Neurosurgery Department of AnesthesiologyLoma Linda University Medical SchoolLoma LindaUSA

Bibliographic information

  • Book Title Animal Models of Acute Neurological Injuries
  • Editors Jun Chen
    Xiao-Ming Xu
    Zao C. Xu
  • Series Title Springer Protocols Handbooks
  • Series Abbreviated Title Springer Protocols Handbooks
  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-1-60327-184-4
  • Softcover ISBN 978-1-61737-877-5
  • eBook ISBN 978-1-60327-185-1
  • Series ISSN 1949-2448
  • Series E-ISSN 1949-2456
  • Edition Number 1
  • Number of Pages XXI, 498
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neurosciences
    Animal Models
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


From the reviews:

"In this book, the editors have provided detailed discussions on numerous models of acute neurologic injury … . an invaluable resource to anyone starting out in the neuroinjury field or to experienced individuals who require an update in terms of animal modeling. … I recommend this book to … investigators in the field of neurologic injuries, including students, basic scientists, and clinicians. I think anyone in the field of experimental or clinical neurologic disorders will find this book to be extremely helpful … ." (American Journal of Neuroradiology, Vol. 30, March, 2009)