From Local Invasion to Metastatic Cancer

Involvement of Distant Sites Through the Lymphovascular System

  • Stanley P. L. Leong

Part of the Current Clinical Oncology book series (CCO)

Table of contents

  1. Front Matter
    Pages i-xxviii
  2. Innovation and Experience

    1. Front Matter
      Pages 1-1
    2. Simone John, Christina H. Stuelten, John E. Niederhuber
      Pages 3-10
    3. Takashi Aikou, Yuko Kitagawa, Yoshikazu Uenosono, Shoji Natsugoe, Anton J. Bilchik, Naoto T. Ueno
      Pages 29-43
    4. Hiroo Suami, Wei-Ren Pan, G. Ian Taylor
      Pages 45-55
    5. Douglas Reintgen, Blake Cady, Stanley P.L. Leong
      Pages 57-66
  3. Tumor Microenvironment and Proliferation

    1. Front Matter
      Pages 67-67
    2. Richard E.B. Seftor, Elisabeth A. Seftor, Lynne-Marie Postovit, Mary J.C. Hendrix
      Pages 69-73
  4. Lymphangiogenesis and Angiogenesis

    1. Front Matter
      Pages 75-75
    2. Antje Neeb, Jonathan P. Sleeman
      Pages 93-104
  5. Diagnostic Imaging of Cancer

    1. Front Matter
      Pages 105-105
    2. Marika Decyk, Yuko Kono, Robert Mattrey
      Pages 115-122
    3. Antonia Woehnl, Carl K. Hoh, Jeanette Méndez, Denise D. Darrah, Richard C. Orahood, David R. Vera et al.
      Pages 123-133
    4. Edwin C. Glass, Emily Iker
      Pages 135-157
    5. Jean L. Alberini, Myriam Wartski, Veronique Edeline, Olivier Madar, Soraya Banayan, Dominique Bellet et al.
      Pages 169-175
  6. Therapeutic Targeting of the Lymphovascular System

  7. Molecular Mechanisms of Metastasis

    1. Front Matter
      Pages 209-209
    2. S. David Nathanson, Cathie G. Miller, James H. Paxton
      Pages 211-226
    3. Minoru Kitago, Steve R. Martinez, Takuji Mori, Kazuo Koyanagi, Naoyuki Umetani, Roderick R. Turner et al.
      Pages 227-235
    4. Catherine Alix-Panabières, Hope S. Rugo, John W. Park, Klaus Pantel
      Pages 237-241
    5. Michael Detmar
      Pages 255-261
    6. Darryl A. Oble, F. Stephen Hodi, Gregory Y. Lauwers, Glenn Dranoff, Martin C. Mihm Jr
      Pages 263-279
  8. Molecular Targeted Therapy Against Growth Factor Receptors, Signaling Pathways and Angiogenesis as Therapeutic Targets

    1. Front Matter
      Pages 281-281
    2. Caroline A. Heckman, Tanja Holopainen, Kari Alitalo
      Pages 283-295
    3. Michalis V. Karamouzis, Athanassios Argiris
      Pages 297-307
    4. David Berz, Elise McCormack, Anthony Mega, Harold J. Wanebo
      Pages 309-326
  9. Impact of Nodal Status and Tumor Burden in Sentinel Nodes on the Clinical Outcome

    1. Front Matter
      Pages 327-327
    2. Stanley P.L. Leong
      Pages 329-337
    3. Igor Langer, Ulrich Guller, Carsten Thomas Viehl, Markus Zuber
      Pages 339-345
    4. Sukamal Saha, Saad Sirop, Mehul Soni, Douglas Iddings, David Wiese, Anton J Bilchik et al.
      Pages 361-379
  10. Immune Responses in the Draining Lymph Nodes Against Cancer: Implication for Immunotherapy

    1. Front Matter
      Pages 389-389
    2. Walter T. Lee, Suyu Shu
      Pages 391-400
    3. Rong Rong Huang, Eijun Itakura, Duan-Ren Wen, Alistair J. Cochran
      Pages 401-406
  11. The Role of Stem Cells in Cancer Metastasis

    1. Front Matter
      Pages 433-433
    2. Jim B. Boonyaratanakornkit, Janellen E. Smith, Ruby Ghadially
      Pages 435-441
    3. Maziyar A. Kalani, Piero Dalerba, Michael F. Clarke
      Pages 443-453

About this book


In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.


Carcinom Staging angiogenesis cancer lymphangiogenesis metastasis positron emission tomography sentinel lymph node (SNL)

Editors and affiliations

  • Stanley P. L. Leong
    • 1
  1. 1.Division of Surgical OncologyUniversity of California, San FranciscoSan FranciscoUSA

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Medicine
  • Print ISBN 978-1-60327-086-1
  • Online ISBN 978-1-60327-087-8
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals