© 2007

Arthritis Research

Methods and Protocols Volume 1

  • Andrew P. Cope

Part of the Methods in Molecular Medicine book series (MIMM, volume 135)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Synovial Joint Morphology, Histopathology, and Immunohistochemistry

    1. Front Matter
      Pages 1-1
    2. Ai Lyn Tan, Helen I. Keen, Paul Emery, Dennis McGonagle
      Pages 3-26
    3. Richard J. Reece
      Pages 27-45
    4. Martina Gogarty, Oliver FitzGerald
      Pages 47-63
    5. Stefan Kuchen, Christian A. Seemayer, Michel Neidhart, Renate E. Gay, Steffen Gay
      Pages 65-75
    6. Jörg H. W. Distler, Oliver Distler, Michel Neidhart, Steffen Gay
      Pages 77-90
    7. Ulf Müller-Ladner, Martin Judex, Elena Neumann, Steffen Gay
      Pages 91-104
    8. Jonathan T. Beech, Fionula M. Brennan
      Pages 105-119
    9. Pascal O. van der Hall, Maarten C. Kraan, Paul Peter Tak
      Pages 121-143
  3. Cartilage Matrix and Bone Biology

    1. Front Matter
      Pages 145-145
    2. Ernst B. Hunziker
      Pages 147-166
    3. Barbara Osborn, Yun Bai, Anna H. K. Plaas, John D. Sandy
      Pages 167-182
    4. Samantha N. Redman, Ilyas M. Khan, Simon R. Tew, Charles W. Archer
      Pages 183-199
    5. John S. Mort, Peter J. Roughley
      Pages 201-209
    6. Tim E. Cawston, Tanya G. Morgan
      Pages 211-226
    7. Rosalind M. Hembry, Susan J. Atkinson, Gillian Murphy
      Pages 227-238
    8. Richard D. Evans, Yoshifumi Itoh
      Pages 239-249
    9. Linda Troeberg, Hideaki Nagase
      Pages 251-267
    10. Georg Schett, Birgit Tuerk
      Pages 269-283

About this book


Arthritis Research: Methods and Protocols is a compendium of data pertinent to the methods and protocols that have contributed to recent advances in molecular medicine in general, but to the molecular basis of rheumatic disease in particular. These volumes details novel technologies, some of which are still evolving and whose impacts are yet to be determined. Leaders in the field contribute to cover such exciting and cutting edge topics as imaging and immunohistochemistry, analysis of cartilage and bone catabolism, immunobiology, and cell trafficking.

In Volume 1, authors discuss synovial joint morphology, histopathology, and immunohistochemistry, cartilage matrix and bone biology, and cell trafficking, migration and invasion. Volume 2 is broken up into sections that cover immunobiology and T cells, animal models of arthritis, and applications of new technologies, such as Differential Display Reverse Transcription-Polymerase Chain Reaction (DDRT-PCR), to define novel therapeutic targets. Both volumes combine to produce a concise set of protocols condensing decades of experience and expertise.

Arthritis Research: Methods and Protocols will be a valuable tool for basic research investigators, clinician scientists, pathologists, immunologists, and biochemists looking to stay current in their fields.


Arthritis PCR gene expression gene transfer genes hybridization microscopy transcription

Editors and affiliations

  • Andrew P. Cope
    • 1
  1. 1.The Kennedy Institute of RheumatologyImperial College LondonLondonUK

Bibliographic information

  • Book Title Arthritis Research
  • Book Subtitle Methods and Protocols Volume 1
  • Editors Andrew P. Cope
  • Series Title Methods in Molecular Medicine
  • DOI
  • Copyright Information Humana Press 2007
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-1-58829-344-2
  • Softcover ISBN 978-1-61737-507-1
  • eBook ISBN 978-1-59745-401-8
  • Series ISSN 1543-1894
  • Series E-ISSN 1940-6037
  • Edition Number 1
  • Number of Pages XX, 446
  • Number of Illustrations 99 b/w illustrations, 15 illustrations in colour
  • Topics Orthopedics
    Cell Biology
    Human Genetics
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


From the reviews:

"...offers a comprehensive reference for the analysis of tissues relevant to arthritis research in brief chapters that emphasize how various analyses are performed.  What separates this series from other references in this area is its ability to be brief but thorough in the discussion of technically challenging methods." -Doody's Book Review, Weighted Numerical Score:95 - 4 Stars

"This multiauthored … compendium of arthritis research methods and protocols provides pertinent practical information for the bench researcher as well as for the interested clinician. … It is a worthwhile reference to have in the research laboratory … . I enthusiastically recommend … and believe this publication would have broad appeal to the rheumatologic community and to those in related specialties. … I congratulate the authors on developing an excellent compendium of arthritis research … ." (Robert J. Quinet, JAMA, April, 2008)

"Arthritis Research: Methods and Protocols forms part of a book series on Methods in Molecular Medicine by Humana Press. … Overall the books are extremely useful as both a practical guide and a reference text and are easy to understand. We would recommend the books to anyone with an interest in rheumatology research – basic scientists, clinicians and students … ." (Leonie Taams and Hayley Evans, Immunology News, August, 2008)