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© 2008

Ocular Transporters In Ophthalmic Diseases And Drug Delivery

Ophthalmology Research

  • Joyce Tombran-Tink
  • Colin J. Barnstable

Benefits

  • Focuses on the molecular characteristics, localization, and substrate specificities of several classes of well-known membrane transporters in various compartments of the eye

  • Illustrates how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness

  • Examines how epithelial and endothelial barriers can block drug delivery and limit ocular availability of drugs

Book

Part of the Ophthalmology Research book series (OPHRES)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Transport in the Anterior Segment

    1. Peter S. Reinach, José E. Capó-Aponte, Stefan Mergler, Kathryn S. Pokorny
      Pages 17-46
  3. Transporters of the Ciliary Epithelium

    1. Chi-wai Do, Chi-wing Kong, Chu-yan Chan, Mortimer M. Civan, Chi-ho To
      Pages 61-86
  4. Lens Transporters

    1. Paul J. Donaldson, Julie Lim
      Pages 89-110
    2. Nicholas A. Delamere, Shigeo Tamiya
      Pages 111-123
  5. Transport Across the Blood–Retinal Barrier

  6. Transport Across the Retinal Pigment Epithelium

    1. Adnan Dibas, Thomas Yorio
      Pages 157-184
    2. Paul A. Constable, John G. Lawrenson, N. Joan Abbott
      Pages 235-253
  7. Transporters in the Retina

    1. Paul P. M. Schnetkamp, Yoskiyuki Shibukawa, Haider F. Altimimi, Tashi G. Kinjo, Pratikhya Pratikhya, Kyeong Jing Kang et al.
      Pages 257-273
    2. Vijay Sarthy, David Pow
      Pages 275-292
  8. Genetic Variants of Ocular Transporters

About this book

Introduction

This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye. Ocular Transporters in Ophthalmic Diseases and Drug Delivery is the first text book in this field and offers up-to-date information to clinicians, research scientists in academia, and the pharmaceutical industry. This work has clinical implications for drug development and therapeutic drug delivery, making it an invaluable resource for readers.

Keywords

Biology Diagnostics Ocular Therapeutics Transporters glycoprotein molecular mechanisms regulation

Editors and affiliations

  • Joyce Tombran-Tink
    • 1
  • Colin J. Barnstable
    • 2
  1. 1.Department of Ophthalmology and Visual ScienceYale University School of MedicineNew HavenUSA
  2. 2.Department of Neural andBehavioral SciencesPenn State University College of MedicineHersheyUSA

About the editors

Colin J. Barnstable, D.Phil., is Professor and Chair, Department of Neural and Behavioral Sciences
Director, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute

Joyce Tombran-Tink, PhD, Department of Neural and Behavioral Sciences, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute

Bibliographic information

  • Book Title Ocular Transporters In Ophthalmic Diseases And Drug Delivery
  • Book Subtitle Ophthalmology Research
  • Editors Joyce Tombran-Tink
    Colin J. Barnstable
  • Series Title Ophthalmology Research
  • DOI https://doi.org/10.1007/978-1-59745-375-2
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-58829-958-1
  • Softcover ISBN 978-1-62703-865-2
  • eBook ISBN 978-1-59745-375-2
  • Edition Number 1
  • Number of Pages XVIII, 467
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Ophthalmology
    Cell Biology
  • Buy this book on publisher's site
Industry Sectors
Biotechnology
Health & Hospitals
Pharma

Reviews

From the reviews: “The ophthalmic structures and tissues present a series of mechanisms necessary to homeostasis maintenance, in order to enable and support the vision function. … this book is indicated for physicians, pharmacologists, pharmacotechnicians, and investigators who wish to understand and study the complex processes of transportation and homeostasis of ocular globe, as well as to develop and formulate eye drops or apply therapies in the ophthalmology area.” (Vladi Olga Consiglieri, Brazilian Journal of Pharmaceutical Sciences, 2009)