© 2007

Cytokines in Human Health

Immunotoxicology, Pathology, and Therapeutic Applications

  • Robert V. House
  • Jacques Descotes

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-x
  2. Rob J. Vandebriel
    Pages 17-30
  3. Hervé Lebrec, John Vasilakos
    Pages 31-46
  4. Debra L. Laskin, Vasanthi R. Sunil, Robert J. Laumbach, Howard M. Kipen
    Pages 83-112
  5. Berran Yucesoy, Victor J. Johnson, Michael L. Kashon, Michael I. Luster
    Pages 113-132
  6. Stephen B. Pruett
    Pages 133-173
  7. Peter T. Thomas, Melissa S. Beck-Westermeyer
    Pages 175-191
  8. Jacques Descotes, Thierry Vial
    Pages 193-204
  9. Roxana G. Baluna
    Pages 205-231
  10. Pierre Miossec
    Pages 233-257
  11. Kenneth W. Renton
    Pages 275-296
  12. Thierry Vial, Jacques Descotes
    Pages 319-348
  13. Back Matter
    Pages 349-366

About this book


Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. The first section of the book is devoted to basic concepts of cytokine biology, especially as this relates to the practice of immunotoxicology. Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules. The second section provides a broad understanding of the range of cytokine activity in human disease, describing methods for assessing cytokine immunotoxicity. In the third and final section of the book, the increasingly important use of cytokines as therapeutics is explored in detail. This section includes examinations into the effects of cytokines on the immune system and in treating cancer. Timely and comprehensive, Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications will serve as both a primer and a starting point for a more detailed investigation of the role these fascinating biological regulators play in human health and disease.


Chemokine Endoplasmatisches Reticulum Immune System Immunity autoimmune disease drugs of abuse influence

Editors and affiliations

  • Robert V. House
    • 1
  • Jacques Descotes
    • 2
  1. 1.DyPort Vaccine Company, LLCFrederick
  2. 2.Poison Center and Pharmacovigilance UnitLyon CedexFrance

Bibliographic information

  • Book Title Cytokines in Human Health
  • Book Subtitle Immunotoxicology, Pathology, and Therapeutic Applications
  • Editors Robert V. House
    Jacques Descotes
  • Series Title Methods in Pharmacology and Toxicology
  • DOI
  • Copyright Information Humana Press 2007
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-1-58829-467-8
  • Softcover ISBN 978-1-61737-586-6
  • eBook ISBN 978-1-59745-350-9
  • Series ISSN 1557-2153
  • Series E-ISSN 1940-6053
  • Edition Number 1
  • Number of Pages X, 366
  • Number of Illustrations 21 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
    Cell Biology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Pharmacology & Toxicology
Consumer Packaged Goods


"...unique in the way it ties together several different areas of immunology in the context of the roles of cytokines within various pathophysiological conditions and therapies...a useful reference for those interested in cytokine research." -Doody's Book Review, Weighted Numberical Score: 88 - 3 Stars


" interesting overview of the applications and role of cytokines  in human health and disease, and with large numbers of reference supplied with each chapter it is most certainly a good source of reference material for researchers in the field." -Immunology News

"This book is the latest addition to the ‘Methods in Pharmacology and Toxicology’ series … . The editors, Robert House and Jacques Descotes, are internationally renowned experts in the immunotoxicology field … . Overall, this is a useful volume, which should serve as a good reference source for toxicologists and immunologists working in the immunotoxicology and/or biopharmaceutical fields. The various chapters are concisely written and well referenced … ." (Peter Ryle, BTS Newsletter, Winter 2007)