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Molecular Targeting in Oncology

  • Howard L. Kaufman
  • Scott Wadler
  • Karen Antman

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. General Strategies for Molecular Targeting in Oncology

    1. Front Matter
      Pages 1-1
    2. Chad D. Knights, Richard G. Pestell
      Pages 3-32
    3. John B. Easton, Peter J. Houghton
      Pages 33-53
    4. Joseph A. Sparano
      Pages 55-73
    5. Len Neckers, Percy Ivy
      Pages 75-95
    6. Sam Thiagalingam, Douglas V. Faller
      Pages 97-113
  3. Molecular Targeting for Specific Disease Sites

    1. Front Matter
      Pages 115-115
    2. Mark L. Sundermeyer, Alfonso Bellacosa, Neal J. Meropol
      Pages 133-163
    3. Jonathan D. Schwartz, Josep M. Llovet
      Pages 165-210
    4. Anupama Goel, Peter Kozuch
      Pages 211-226
    5. Cheryl Ho, Angela M. Davies, Primo N. Lara, O. Gautschi, P.C. Mack, Paul H. Gumerlock et al.
      Pages 227-240
    6. Olwen Hahn, Walter Stadler
      Pages 241-261
    7. Elisabeth I. Heath, Michael A. Carducci
      Pages 263-290
    8. Nilofer S. Azad, Gisele Sarosy, Elise C. Kohn
      Pages 291-308
    9. Deena M. Atieh, Linda T. Vahdat
      Pages 309-342
    10. Akshay Gupta, John M. Kirkwood
      Pages 343-367
  4. Classes of Drugs for Molecular Targeting in Oncology

    1. Front Matter
      Pages 369-369
    2. Hossein Borghaei, Liat Binyamin, Igor Astsaturov, Louis M. Weiner
      Pages 371-412
    3. Dan T. Vogl, Alan M. Gewirtz
      Pages 413-429
    4. Takafumi Nakamura, Stephen J. Russell
      Pages 431-445
    5. Miguel-Angel Perales, Jedd D. Wolchok, Howard L. Kaufman
      Pages 447-469
    6. Henry B. Koon, Michael B.Atkins
      Pages 471-507
    7. Monica Bertagnolli, Jaye L. Viner, Ernest T. Hawk
      Pages 509-541
  5. Specific Drugs for Molecular Targeting in Oncology

    1. Front Matter
      Pages 543-543
    2. John Mendelsohn
      Pages 559-571
    3. Shermini Saini, Herbert Hurwitz
      Pages 573-584
    4. M. C. Champaneria, I. M. Modlin, I. Latich, J. Bornschein, I. Drozdov, M. Kidd
      Pages 585-637
  6. Challenges in Molecular Targeting in Oncology

    1. Front Matter
      Pages 639-639
    2. Sarita Dubey, Joan H. Schiller
      Pages 649-655
    3. J.J.E.M. Kitzen, M.J.A. de Jonge, J. Verweij
      Pages 657-674
    4. Lalitha K. Shankar, Anne Menkens, Daniel C. Sullivan
      Pages 675-691
    5. Helen X. Chen, Janet E. Dancey
      Pages 693-705
    6. Joseph E. Tomaszewski, James H. Doroshow
      Pages 707-722
  7. Back Matter
    Pages 723-728

About this book

Introduction

In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more.  Comprehensive and cutting-edge, Molecular Targeting in Oncology is an essential reference for those working in the field.

Keywords

antibody cancer cancer prevention cancer therapy cancer treatment carcinoma cell cytokine melanoma ovarian cancer pancreatic cancer prevention prostate cancer targeted therapy vaccine

Editors and affiliations

  • Howard L. Kaufman
    • 1
  • Scott Wadler
    • 2
  • Karen Antman
    • 3
  1. 1.Division of Surgical OncologyColumbia UniversityNew York
  2. 2.Division of Hematology and Medical Oncology, Department of MedicineWeill Medical College Cornell UniversityNY
  3. 3.Boston University Medical Campus Boston University School of MedicineBoston

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59745-337-0
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-577-4
  • Online ISBN 978-1-59745-337-0
  • Buy this book on publisher's site
Industry Sectors
Pharma
Biotechnology
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