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© 2008

The Role of Microtubules in Cell Biology, Neurobiology, and Oncology

  • Tito Fojo

Benefits

  • Collects the most current microtubule research available

  • Investigates the potential of microtubules in cancer therapy

  • Written by leading anti-cancer researchers

Book

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. John J. Correia, Sharon Lobert
    Pages 21-46
  3. Mary Ann Jordan, Leslie Wilson
    Pages 47-81
  4. Maria Kavallaris, Sima Don, Nicole M. Verrills
    Pages 83-104
  5. Richard F. Ludueña, Asok Banerjee
    Pages 105-121
  6. Richard F. Ludueña, Asok Banerjee
    Pages 123-175
  7. Richard F. Ludueña, Asok Banerjee
    Pages 177-191
  8. Pascal Verdier-Pinard, Fang Wang, Ruth Hogue Angeletti, Susan Band Horwitz, George A. Orr
    Pages 193-210
  9. Eva Nogales, Kenneth H. Downing
    Pages 211-225
  10. Lee M. Greenberger, Frank Loganzo
    Pages 227-258
  11. Susan Band Horwitz, Tito Fojo
    Pages 307-336
  12. Paraskevi Giannakakou, James P. Snyder
    Pages 357-394
  13. Chris H. Takimoto, Muralidhar Beeram
    Pages 395-419
  14. Lyudmila A. Vereshchagina, Orit Scharf, A. Dimitrios Colevas
    Pages 421-478
  15. Manon Carré, Diane Braguer
    Pages 479-518
  16. Raffaella Giavazzi, Katiuscia Bonezzi, Giulia Taraboletti
    Pages 519-530

About this book

Introduction

The family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This field of investigation is a testament to how important both basic and clinical sciences are in understanding disease mechanisms and making inroads into therapies. Microtubule Targets in Cancer Therapy presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available. Among the topics examined in this volume are compounds that interact with tubulin, mechanisms and regulation by microtubule-associated proteins and drugs, MAPs, the tubulin superfamily its isotopes, peptides and depsipeptides, and neurodegenerative diseases.

Without the basic scientific knowledge that has been accumulated – to which the contributors of this work have contributed greatly – we would not be in the position we find ourselves as we increasingly understand disease and advancing therapies. Microtubule Targets in Cancer Therapy contributes to this new knowledge, and the text will be an invaluable resource for cancer researchers, oncologists, pharmacologists, and medical chemists.

Keywords

Isotop apoptosis biology cell biology distribution

Editors and affiliations

  • Tito Fojo
    • 1
  1. 1.Medical Oncology Branch, Center for Cancer ResearchNational Cancer InstituteBethesda

Bibliographic information

  • Book Title The Role of Microtubules in Cell Biology, Neurobiology, and Oncology
  • Editors Antonio Tito Fojo
  • Series Title Cancer Drug Discovery and Development
  • DOI https://doi.org/10.1007/978-1-59745-336-3
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-58829-294-0
  • Softcover ISBN 978-1-62703-861-4
  • eBook ISBN 978-1-59745-336-3
  • Edition Number 1
  • Number of Pages XVII, 587
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cancer Research
    Oncology
    Pharmacology/Toxicology
    Medicinal Chemistry
  • Buy this book on publisher's site
Industry Sectors
Biomedicine
Pharma
Health & Hospitals
Biotechnology
Oncology & Hematology
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Reviews

From the reviews:

"This book is appropriate for laboratories with an interest in the biology of microtubules … . Each chapter is nicely illustrated, well referenced, and offers a timely evaluation of what is known about tubulin and microtubules, including how they are targeted therapeutically. … The color insert and the accompanying CD-ROM with all color figures are helpful. This is an excellent all-around reference appropriate for researchers or clinicians interested in the basic science of tubulins, microtubules, related diseases, and targeted therapy."(John D. Robertson, Doody’s Review Service, January, 2009)

“This book offers a wide and detailed discussion of drugs and methods for studying tubulins and microtubules … . The book is easy-reading and well organized by … well-detailed and itemized methodology of study, a helpful conclusion including tips for future interested investigators, and a long list of references serving a specific source of search. … Chapters added in the end of the book … very nicely wrap up the book for those interested in these areas and hopefully intending to acquire acknowledgement about it.” (Fábio Luís Forti, Brazilian Journal of Pharmaceutical Sciences, Vol. 47 (2), Summer, 2011)