The Role of Microtubules in Cell Biology, Neurobiology, and Oncology

  • Tito Fojo

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. John J. Correia, Sharon Lobert
    Pages 21-46
  3. Mary Ann Jordan, Leslie Wilson
    Pages 47-81
  4. Maria Kavallaris, Sima Don, Nicole M. Verrills
    Pages 83-104
  5. Richard F. Ludueña, Asok Banerjee
    Pages 105-121
  6. Richard F. Ludueña, Asok Banerjee
    Pages 123-175
  7. Richard F. Ludueña, Asok Banerjee
    Pages 177-191
  8. Pascal Verdier-Pinard, Fang Wang, Ruth Hogue Angeletti, Susan Band Horwitz, George A. Orr
    Pages 193-210
  9. Eva Nogales, Kenneth H. Downing
    Pages 211-225
  10. Lee M. Greenberger, Frank Loganzo
    Pages 227-258
  11. Susan Band Horwitz, Tito Fojo
    Pages 307-336
  12. Paraskevi Giannakakou, James P. Snyder
    Pages 357-394
  13. Chris H. Takimoto, Muralidhar Beeram
    Pages 395-419
  14. Lyudmila A. Vereshchagina, Orit Scharf, A. Dimitrios Colevas
    Pages 421-478
  15. Manon Carré, Diane Braguer
    Pages 479-518
  16. Raffaella Giavazzi, Katiuscia Bonezzi, Giulia Taraboletti
    Pages 519-530
  17. André Delacourte, Nicolas Sergeant, Luc Buée
    Pages 531-558
  18. Back Matter
    Pages 577-587

About this book


The family of proteins called the tubulin and the microtubules they form when they aggregate are extremely important in the cell and, as we are increasingly learning, important in diseases that afflict so many. This field of investigation is a testament to how important both basic and clinical sciences are in understanding disease mechanisms and making inroads into therapies. Microtubule Targets in Cancer Therapy presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available. Among the topics examined in this volume are compounds that interact with tubulin, mechanisms and regulation by microtubule-associated proteins and drugs, MAPs, the tubulin superfamily its isotopes, peptides and depsipeptides, and neurodegenerative diseases.

Without the basic scientific knowledge that has been accumulated – to which the contributors of this work have contributed greatly – we would not be in the position we find ourselves as we increasingly understand disease and advancing therapies. Microtubule Targets in Cancer Therapy contributes to this new knowledge, and the text will be an invaluable resource for cancer researchers, oncologists, pharmacologists, and medical chemists.


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Editors and affiliations

  • Tito Fojo
    • 1
  1. 1.Medical Oncology Branch, Center for Cancer ResearchNational Cancer InstituteBethesda

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-294-0
  • Online ISBN 978-1-59745-336-3
  • Buy this book on publisher's site
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Oncology & Hematology
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