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© 2008

Genomics in Endocrinology

DNA Microarray Analysis in Endocrine Health and Disease

  • Stuart Handwerger
  • Bruce Aronow
Book

Part of the Contemporary Endocrinology book series (COE)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Hormone Action and Molecular Mechanisms

    1. Front Matter
      Pages 23-23
    2. Amilcar Flores-Morales, Leandro Fernández-Pérez
      Pages 41-66
    3. Clay E.S. Comstock, Craig J. Burd, Walter J. Jessen, Karen E. Knudsen
      Pages 83-113
    4. Anelia Horvath, Constantine A. Stratakis
      Pages 131-143
  4. Endocrine Producing Tissues

  5. Diseases of Hormonal Systems

  6. Back Matter
    Pages 283-288

About this book

Introduction

In recent years, the development of new technologies capable of monitoring genome function has resulted in fewer hopeful estimates and increasingly solid depictions of genome output from individual samples. Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The volume provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed are the methodology of DNA microarrays and general methods for the analysis of microarray data, as well as studies of a wide variety of normal and abnormal endocrine cells.

In the introductory chapter, the volume’s editors describe several issues in hypothesis formulation, experimental design, data analysis, and follow-up studies that may corroborate, validate, and extend hypotheses gained through microarray analyses. The contributed chapters span a variety of applications that we have divided into the areas of (1) genomic insights into molecular mechanisms responsible for hormone action, (2) genomic characterizations of endocrine producing tissues, and (3) genomic manifestations of diseases of hormonal systems.

A volume on the cutting-edge of technology, Genomics in Endocrinology will provide researchers with an authoritative volume on the most recent advances in monitoring genome function.

Keywords

Abnormal endocrine cells DNA DNA microarrays Diabetes Microarray Normal endocrine cells Transcription factors estrogen receptor gene expression genes hormone signaling molecular mechanisms prolactin receptor signaling transcription

Editors and affiliations

  • Stuart Handwerger
    • 1
  • Bruce Aronow
    • 2
  1. 1.Cincinnati Children’s Hospital Medical Center (CCHMC)University of Cincinnati College of MedicineCincinnatiUSA
  2. 2.University of Cincinnati College of MedicineCincinnatiUSA

Bibliographic information

  • Book Title Genomics in Endocrinology
  • Book Subtitle DNA Microarray Analysis in Endocrine Health and Disease
  • Editors Stuart Handwerger
    Bruce J. Aronow
  • Series Title Contemporary Endocrinology
  • DOI https://doi.org/10.1007/978-1-59745-309-7
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-58829-651-1
  • Softcover ISBN 978-1-62703-874-4
  • eBook ISBN 978-1-59745-309-7
  • Edition Number 1
  • Number of Pages XI, 288
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Endocrinology
    Cell Biology
    Human Genetics
    Microbiology
  • Buy this book on publisher's site
Industry Sectors
Biotechnology
Health & Hospitals
Internal Medicine & Dermatology
Pharma

Reviews

From the reviews:

"This book is intended to introduce endocrinologists to the field of genomic analysis including both wet-bench and downstream analysis/interpretation. The work is nicely broken into application areas by field of endocrinology and therefore presents the material in a way that should be interesting to readers and applicable to their particular questions. … The material is presented across several levels and therefore different portions should be of use to trainees, starting at the graduate level, through experienced principal investigators. … a good addition to the canon." (Gene C Webb, Doody’s Review Service, March, 2008)

"This book is aimed to bridge between the advanced knowledge acquired by new technologies in genetics and endocrinology, such as the use of microarrays. … For geneticists and endocrinologists." (Pediatric Endocrinology Reviews, Vol. 5 (4), June, 2008)

“Contemporary Endocrinology series provides the necessary insight into DNA microarray technology and some of its applications in endocrinology, serving as a critical guide to scientists using the technology, as well as a primary source of information for the clinical endocrinologists, about the results obtained to date. … This volume is an indispensable guide to the new and exciting world of genome-wide transcription analysis and its applications in endocrinology.” (Serban Radian, Acta Endocrinologica, Vol. 1, 2009)