© 2008

Transforming Growth Factor-β in Cancer Therapy, Volume I

Basic and Clinical Biology

  • In-depth detail of basic concepts of TGF-ß in normal physiology and cancer pathobiology

  • Conveniently divided into three easy-to-follow parts

  • Companion volume details cancer treatments and therapies


Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Basic Concepts of TGF-β Signaling in Normal Physiology and Cancer Pathobiology

    1. Front Matter
      Pages 1-1
    2. Vesna Todorovic, Daniel B. Rifkin
      Pages 37-55
    3. Marko Hyytiäinen, Katri Koli, Jorma Keski-Oja
      Pages 57-75
    4. Azeddine Atfi, Marie-Francoise Bourgeade
      Pages 77-90
    5. Qunyan Jin, Guofeng Gao, Kathleen M. Mulder
      Pages 169-184
    6. Tae-Aug Kim, Seong-Jin Kim
      Pages 199-211
    7. Leslie I. Gold, Jon Lecanda
      Pages 213-242
    8. Arja Band, Marikki Laiho
      Pages 243-257
    9. Sylvie Thuault, Ulrich Valcourt, Marcin Kowanetz, Aristidis Moustakas
      Pages 259-273
    10. Christina H. Stuelten, Anita B. Roberts, William G. Stetler-Stevenson
      Pages 275-292
    11. Irwin M. Liu, Stephen H. Schilling, Xiao-Fan Wang
      Pages 293-303

About this book


Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor-ß signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor-ß superfamily members in normal and tumor biology. Part III details transforming growth factor-ß in inflammation and fibrosis.

This volume’s companion, Cancer Treatment and Therapy, examines transforming growth factor-ß in several developing and advanced cancers and discusses methods of treatment and therapy. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.


Carcinom biological functions gene therapy genes physiology signal transduction transcription

Authors and affiliations

  1. 1.Cancer Training Branch, Office of Centers, Training and ResourcesNational Cancer InstituteBethesda

Bibliographic information

  • Book Title Transforming Growth Factor-β in Cancer Therapy, Volume I
  • Book Subtitle Basic and Clinical Biology
  • Editors Sonia B. Jakowlew
  • Series Title Cancer Drug Discovery and Development
  • DOI
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-58829-714-3
  • Softcover ISBN 978-1-61737-735-8
  • eBook ISBN 978-1-59745-292-2
  • Edition Number 1
  • Number of Pages XXIV, 735
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Oncology
    Cell Biology
    Cancer Research
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology


From the reviews:

"This volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology. … will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease … . also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells." (James P Luyendyk, Doody’s Review Service, May, 2008)