© 2008

Wnt Signaling

Pathway Methods and Mammalian Models

  • Elizabeth Vincan

Part of the Methods in Molecular Biology™ book series (MIMB, volume 468)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Wnt Signaling Pathway Methods

    1. Canonical Wnt/FZD Signaling

      1. Vladimir Wolf, Yoshimi Endo, Jeffrey S. Rubin
        Pages 31-44
      2. Adam R. Cole, Calum Sutherland
        Pages 45-65
      3. Andrei V. Ougolkov, Daniel D. Billadeau
        Pages 67-75
      4. Nick Barker, Maaike van den Born
        Pages 91-98
      5. Otto Schmalhofer, Simone Spaderna, Thomas Brabletz
        Pages 111-128
    2. Non-Canonical Signaling

      1. Richard G. James, William H. Conrad, Randall T. Moon
        Pages 131-144
      2. Christina M. Freisinger, Douglas W. Houston, Diane C. Slusarski
        Pages 145-156
      3. Samudra K. Dissanayake, Ashani T. Weeraratna
        Pages 157-172
      4. John D. Doran, Marc D. Jacobs
        Pages 197-205
      5. Mireille Montcouquiol, Jennifer M. Jones, Nathalie Sans
        Pages 207-219
  3. Mammalian Model Systems for Wnt/FZD Function

    1. Kestutis Planutis, Marina Planutiene, Randall F. Holcombe
      Pages 231-241
    2. Michael P. O'Connell, Amanda D. French, Poloko D. Leotlela, Ashani T. Weeraratna
      Pages 243-253

About this book


Since their discovery, Wnt signaling molecules have been shown to control key events in embryogenesis, to maintain tissue homeostasis in the adult and, when aberrantly activated, to promote human degenerative diseases and cancer, thus making them a vital area of study.  Wnt Signaling: Methods and Protocols examines both biochemical assays and vertebrate and invertebrate model systems to provide a point of reference to current molecular protocols and the diverse model systems employed to study this important signaling pathway.  In Volume 1, Pathway Methods and Mammalian Models, assays to measure activation of the diverse Wnt signaling pathways are explored, along with a selection of models and strategies used to study mammalian Wnt/FZD fuction, from protein-protein interaction and simple cell line models to organoid cultures and mouse models.  As a volume in the highly successful Methods in Molecular Biology™ series, chapters contain readily reproducible laboratory protocols, complete with lists of necessary equipment and reagents and the Notes section, which reveals helpful troubleshooting tips.


Comprehensive and cutting-edge, Wnt Signaling: Methods and Protocols collects the expertise and knowledge of many leaders in the field to produce this invaluable two-volume resource. 


Activation Calcium Canonical Wnt/FZD signaling Degenerative diseases and cancer Embryogenesis Non-canonical signaling Promoter Protein-protein interaction Tissue homeostasis Wnt/FZD function genes molecular biology proteins tissue transcription

Editors and affiliations

  • Elizabeth Vincan
    • 1
  1. 1.University of MelbourneParkvilleAustralia

Bibliographic information

  • Book Title Wnt Signaling
  • Book Subtitle Pathway Methods and Mammalian Models
  • Editors Elizabeth Vincan
  • Series Title Methods in Molecular Biology™
  • DOI
  • Copyright Information Humana Press 2008
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-1-58829-912-3
  • Softcover ISBN 978-1-61737-841-6
  • eBook ISBN 978-1-59745-249-6
  • Series ISSN 1064-3745
  • Series E-ISSN 1940-6029
  • Edition Number 1
  • Number of Pages XVI, 336
  • Number of Illustrations 74 b/w illustrations, 2 illustrations in colour
  • Topics Cell Biology
  • Buy this book on publisher's site
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