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Regulation of Gene Expression

Molecular Mechanisms

  • Gary H. Perdew
  • John P. Vanden Heuvel
  • Jeffrey M. Peters

Table of contents

  1. Front Matter
    Pages i-ix
  2. Gene Expression Control At The Mrna Level

    1. Front Matter
      Pages 1-2
    2. Pages 3-9
    3. Pages 31-48
    4. Back Matter
      Pages 141-146
  3. Regulation Of Protein Levels And Transcription Factor Function

    1. Front Matter
      Pages 147-148
    2. Pages 149-153
    3. Pages 161-172
    4. Back Matter
      Pages 259-261
  4. Use Of Transgenic And Knockout Mice To Study Gene Regulation

    1. Front Matter
      Pages 265-266
    2. Pages 267-269
    3. Pages 295-318
    4. Back Matter
      Pages 321-328
  5. Back Matter
    Pages 329-333

About this book

Introduction

Regulation of Gene Expression: Molecular Mechanisms presents a comprehensive overview of methods and approaches for characterizing mechanisms of gene regulation. The text is appropriate both as a graduate textbook and a standard laboratory reference and provides the essential groundwork for an advanced understanding of the various mechanisms that may result in altered activity of a specific cell protein.
Each of three sections explores mechanisms of gene regulation and expression, and presents methods and protocols for achieving specific experimental goals. Part I focuses on approaches for studying control of mRNA expression and determining target genes for a given transcription copy. Part II outlines the methods for determining how proteins can regulate each other by mediating synthesis, degradation, protein-protein interactions, and posttranslational modification. Part III explores how gene targeting techniques in mice can provide insight into protein function. This volume provides a clear, concise overview of the protocols and techniques used to examine chemically or disease-mediated alterations in gene expression in mammalian systems.

Keywords

Proteomics RNA Termination Translation cell lines gene expression genes molecular mechanisms proteins transcription transgenic animals

Editors and affiliations

  • Gary H. Perdew
    • 1
  • John P. Vanden Heuvel
    • 1
  • Jeffrey M. Peters
    • 1
  1. 1.Center for Molecular Toxicology and Carcinogenesis Department of Veterinary and Biomedical SciencesThe Pennsylvania State UniversityUniversity Park

Bibliographic information

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