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© 2007

Gene Therapy for Cancer

  • Kelly K. Hunt
  • Stephan A. Vorburger
  • Stephen G. Swisher
Book

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Vectors

    1. Front Matter
      Pages 1-1
    2. Bingliang Fang, Jack A. Roth
      Pages 3-22
    3. Renata Stripecke, Noriyuki Kasahara
      Pages 39-71
    4. Sricharan Chalikonda, David L. Bartlett
      Pages 73-85
    5. Kenneth Lundstrom
      Pages 109-119
    6. Selvarangan Ponnazhagan
      Pages 141-155
    7. Pui-yan Lee, Leaf Huang
      Pages 157-170
  3. Gene Therapy Approaches

    1. Front Matter
      Pages 171-171
    2. Chao-Zhong Song
      Pages 185-196
    3. Masato Yamamoto, David T. Curiel
      Pages 197-212
    4. Richard H. Pin, Maura Reinblatt, Yuman Fong, William R. Jarnagin
      Pages 213-222
    5. Terry L. Timme, Tetsuo Fujita, Hongyu Wang, Koji Naruishi, Dov Kadmon, Robert J. Amato et al.
      Pages 223-241
    6. Anupama Munshi, Raymond E. Meyn
      Pages 243-256
    7. Steven R. Little, Daniel G. Anderson, Robert S. Langer
      Pages 281-300

About this book

Introduction

The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes. Unlike the treatment of genetic defects, where expr- sion of the corrected gene needs to be strong, permanent and, sometimes regulated, tactics to treat tumors can be based on temporary and locally limited effects. In addition, cancer cells have different properties than normal cells and this allows for targeting gene therapy to specific cells, a major advantage over current antitumor therapies, which are also toxic to normal cells and tissues.

Keywords

angiogenesis apoptosis cancer treatment clinical trial gene therapy gene transfer hematopoietic stem cell immune system metastasis ovarian cancer stem cells tumor

Editors and affiliations

  • Kelly K. Hunt
    • 1
  • Stephan A. Vorburger
    • 2
  • Stephen G. Swisher
    • 1
  1. 1.The University of Texas M. D. Anderson Cancer CenterHouston
  2. 2.Inselspital BernUniversity of BernBernSwitzerland

Bibliographic information

  • Book Title Gene Therapy for Cancer
  • Editors Kelly K. Hunt
    Stephan A. Vorburger
    Stephen G. Swisher
  • Series Title Cancer Drug Discovery and Development
  • DOI https://doi.org/10.1007/978-1-59745-222-9
  • Copyright Information Humana Press Inc. 2007
  • Publisher Name Humana Press
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-58829-472-2
  • Softcover ISBN 978-1-61737-590-3
  • eBook ISBN 978-1-59745-222-9
  • Edition Number 1
  • Number of Pages XII, 469
  • Number of Illustrations 69 b/w illustrations, 16 illustrations in colour
  • Topics Oncology
    Hematology
    Cancer Research
  • Buy this book on publisher's site
Industry Sectors
Biotechnology
Health & Hospitals
Oncology & Hematology
Pharma

Reviews

From the reviews:

"The book is divided into 3 sections. … this book is informative and provides a comprehensive review of the advances and limitations of cancer gene therapy. … Overall, the book provides enjoyable and instructive reading material. I highly recommend this book to scientists as well as clinicians as a reference source for cancer gene therapy. Readers would benefit from this excellent reading material, whether they are relatively new to this subspecialty or are actively working within the field of cancer gene therapy." (Prem Seth, JAMA, Vol. 299 (11), 2008)

"Gene Therapy for Cancer … covers the current technologies of cancer gene therapy as well as the difficult task of applying these in clinical trials. … The book also benefits through its helpful tables, drawings and illustrations. … Gene Therapy for Cancer provides a good overview of currently available techniques for cancer gene therapy and their limitations and potential for clinical applications. The book is a useful addition to the library of both researchers and clinicians working in the field." (S. Schepelmann and C. J. Springer, British Journal of Cancer, Vol. 98 (3), 2008)

“This new volume in Humana’s series is written for oncologists, hematologists, cancer researchers, geneticists.” (Tumori, Vol. 93, 2007)