© 2009

Opiate Receptors and Antagonists

From Bench to Clinic

  • Reginald L. DeanIII
  • Edward J. Bilsky
  • S. Stevens Negus


  • Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes

  • Highlights differences and similarities between the opioid pharmacology of animals and human

  • Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence

  • Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications


Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Opioid Receptors

    1. Lindsay H. Burns, Todd W. Vanderah, Hoau-Yan Wang
      Pages 3-17
    2. Ellen M. Unterwald, Richard D. Howells
      Pages 19-44
    3. Mark K. Greenwald, Caren L. Steinmiller
      Pages 45-65
    4. Jonathan Moorman, Zhi Qiang Yao, Edward J. Bilsky, Deling Yin
      Pages 67-80
  3. Opioid Antagonists: Chemistry and Pharmacology

    1. Jean M. Bidlack, Jennifer L. Mathews
      Pages 83-97
    2. Cécile Béguin, Bruce M. Cohen
      Pages 99-118
    3. Beatriz Fioravanti, Todd W. Vanderah
      Pages 119-136
    4. Richard B. Rothman, Subramaniam Ananthan, Edward J. Bilsky
      Pages 137-151
    5. Chun-Su Yuan, Robert J. Israel
      Pages 175-198
  4. Substance Abuse

    1. Kevin A. Sevarino, Thomas R. Kosten
      Pages 227-245
    2. Lindsay H. Burns, Francesco Leri, Mary C. Olmstead
      Pages 247-261
    3. B. Le Foll, Zuzana Justinova, G. Tanda, Marcello Solinas, Peter Selby, Steven R. Goldberg
      Pages 299-314
    4. Andrea King, Rachel Torello, Suchitra Krishnan-Sarin, Stephanie O'Malley
      Pages 315-332
  5. Alcohol and Ingestive Behaviors

About this book


The evolution in our understanding of Opioid receptors and their subtypes is intimately linked to the development of new pharmacological treatments for diseases and disorders as diverse as addiction, self-injurious behavior, pain, cancer, inflammation, eating disorders, traumatic injury, pruritis and movement disorders. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent efforts from leading international scientists and clinicians making use of the latest information emerging from the study of the opioid-receptor system. The authors use a variety of experimental and clinical approaches involving the fields of molecular biology, biochemistry, anatomy, pharmacology, behavioral neuroscience and psychiatry to illustrate rapidly developing experimental and therapeutic areas. Highlights include characterization of opioid receptors, chemistry and pharmacology of opiod antagonists for various receptor subtypes (Mu, Kappa, and Delta), discussion of therapeutic uses of opiod antagonists and exploration of innovative approaches to therapeutic drug delivery.

Opioid Receptors and Antagonists: From Bench to Clinic offers a comprehensive view of recent work on opiod antagonist applications and uses in various clinical treatments. Emphasis is placed on disorders of the reward system. This volume serves as reference while also illuminating prospects for future research.


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Editors and affiliations

  • Reginald L. DeanIII
    • 1
  • Edward J. Bilsky
    • 2
  • S. Stevens Negus
    • 3
  1. 1.Life Sciences/ToxicologyAlkermes, Inc.CambridgeUSA
  2. 2.Department of Pharmacology, College of Osteopathic MedicineUniversity of New EnglandBiddlefordUSA
  3. 3.Department of Pharmacology and ToxicologyVirginia Commonwealth UniversityRichmondUSA

Bibliographic information

  • Book Title Opiate Receptors and Antagonists
  • Book Subtitle From Bench to Clinic
  • Editors Reginald Dean
    Edward J. Bilsky
    S. Stevens Negus
  • Series Title Contemporary Neuroscience
  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-58829-881-2
  • Softcover ISBN 978-1-61737-822-5
  • eBook ISBN 978-1-59745-197-0
  • Edition Number 1
  • Number of Pages XXIII, 757
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Pharmacology & Toxicology
Consumer Packaged Goods


From the reviews:

“The authors do an excellent job of providing insight into the background of the many factors related to opioid receptor antagonists. … Overall, this work is a well written and interesting text and would be a very useful addition to the personal libraries of those medicinal chemists with a research interest in the modulation of the opioid receptor system.” (Thomas E. Prisinzano, Journal of Medicinal Chemistry, Vol. 53 (2), March, 2010)

“This book is focused on the therapeutic uses of opioid antagonists ranging from classical opioid antagonists to novel chemical entities. In any therapeutic field examined, the aim of book as outlined by the title–‘From Bench to Clinic’–is achieved. … The clinical applications of opioid antagonists are extensively discussed in almost all chapters of this book … . In conclusion, this book gives an interesting analysis of the different fields of knowledge and research concerning therapeutic uses of opioid antagonists in recent years.” (Agostino Marrazzo, ChemBioChem, Vol. 5, 2010)