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The Serotonin Receptors

From Molecular Pharmacology to Human Therapeutics

  • Bryan L. Roth

Part of the The Receptors book series (REC)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Marilyn A. Davies, Chiao-ying Chang, Bryan L. Roth
    Pages 59-90
  3. Justin H. Turner, Andrew K. Gelasco, Henry B. Ayiku, Sonya D. Coaxum, John M. Arthur, Maria N. Garnovskaya
    Pages 143-206
  4. Joël Bockaert, Carine Bécamel, Lara Joubert, Sophie Gavarini, Aline Dumuis, Philippe Marin
    Pages 237-255
  5. Zongqi Xia, Douglas J. Sheffler, Bryan L. Roth
    Pages 257-276
  6. Laurent Descarries, Virginia Cornea-Hébert, Mustapha Riad
    Pages 277-317
  7. Guadalupe Mengod, M. Teresa Vilaró, Roser Cortés, Juan F. López-Giménez, Andreu Raurich, José M. Palacios
    Pages 319-364
  8. Andrew J. Thompson, Li Zhang, Sarah C. R. Lummis
    Pages 439-457
  9. Frank Lezoualc’h, Magali Berthouze
    Pages 459-479
  10. Rudy Schreiber, Andrew Sleight, Marie Woolley
    Pages 495-515
  11. Peter B. Hedlund, J. Gregor Sutcliffe
    Pages 517-535
  12. Miles Berger, Laurence H. Tecott
    Pages 537-575
  13. Back Matter
    Pages 607-618

About this book

Introduction

The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding.

Keywords

Nervous System biology brain dementia depression drug drug discovery genome molecular biology neuroanatomy neurotransmitter pharmacology physiology schizophrenia serotonin

Editors and affiliations

  • Bryan L. Roth
    • 1
  1. 1.Department of BiochemistryCase Western Reserve University-School of MedicineCleveland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59745-080-5
  • Copyright Information Humana Press Inc. 2006
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-568-2
  • Online ISBN 978-1-59745-080-5
  • Buy this book on publisher's site
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Biotechnology
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