The Serotonin Receptors

1. Front Matter

   Pages i-xvii

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2. Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors

   • Wesley K. Kroeze, Bryan L. Roth

   Pages 1-38

3. Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes

   • Richard B. Westkaemper, Bryan L. Roth

   Pages 39-58

4. Polymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure

   • Marilyn A. Davies, Chiao-ying Chang, Bryan L. Roth

   Pages 59-90

5. Strategies for the Development of Selective Serotonergic Agents

   • Richard A. Glennon

   Pages 91-142

6. 5-HT Receptor Signal Transduction Pathways

   • Justin H. Turner, Andrew K. Gelasco, Henry B. Ayiku, Sonya D. Coaxum, John M. Arthur, Maria N. Garnovskaya

   Pages 143-206

7. Agonist-Directed Trafficking of 5-HT Receptor-Mediated Signal Transduction

   • Kelly A. Berg, William P. Clarke

   Pages 207-235

8. Identification of 5-HT2 and 5-HT4 Receptor-Interacting Proteins

   • Joël Bockaert, Carine Bécamel, Lara Joubert, Sophie Gavarini, Aline Dumuis, Philippe Marin

   Pages 237-255

9. 5-HT Receptor-Associated Proteins (FRAPs)

   • Zongqi Xia, Douglas J. Sheffler, Bryan L. Roth

   Pages 257-276

10. Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System

    • Laurent Descarries, Virginia Cornea-Hébert, Mustapha Riad

    Pages 277-317

11. Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain

    • Guadalupe Mengod, M. Teresa Vilaró, Roser Cortés, Juan F. López-Giménez, Andreu Raurich, José M. Palacios

    Pages 319-364

12. Modulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D Receptors

    • Pau Celada, Albert Adell, Francesc Artigas

    Pages 365-401

13. Electrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions

    • Evelyn K. Lambe, George K. Aghajanian

    Pages 403-417

14. The Emergence of 5-HT2B Receptors as Targets to Avoid in Designing and Refining Pharmaceuticals

    • Vincent Setola, Bryan L. Roth

    Pages 419-438

15. The 5-HT3 Receptor

    • Andrew J. Thompson, Li Zhang, Sarah C. R. Lummis

    Pages 439-457

16. 5-HT3 and 5-HT4 Receptors as Targets for Drug Discovery for Dementia

    • Frank Lezoualc’h, Magali Berthouze

    Pages 459-479

17. Electrophysiological Properties of Gαs-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7)

    • Rodrigo Andrade

    Pages 481-494

18. 5-HT6 Receptors as Targets for the Treatment of Cognitive Deficits in Schizophrenia

    • Rudy Schreiber, Andrew Sleight, Marie Woolley

    Pages 495-515

19. 5-HT7 Receptors as Favorable Pharmacological Targets for Drug Discovery

    • Peter B. Hedlund, J. Gregor Sutcliffe

    Pages 517-535

20. Serotonin System Gene Knockouts

    • Miles Berger, Laurence H. Tecott

    Pages 537-575

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

• Nervous System
• biology
• brain
• dementia
• depression
• drug
• drug discovery
• genome
• molecular biology
• neuroanatomy
• neurotransmitter
• pharmacology
• physiology
• schizophrenia
• serotonin

From the reviews:

"This is a compilation of reviews regarding various aspects of serotonin receptor structure and function. … As a set of reviews, the book can be read by a broad scientific audience. Material of interest to senior scientists and research fellows is present. … Investigators wishing an up-to-date review of this field will find this book valuable. Those with selected interest, whether evolutionary or structural, will also find useful material. … is a good, comprehensive set of reviews. … overall, it is a valuable book." (Eugene A Davidson, Doody’s Review Service, February, 2007)

• Department of Biochemistry, Case Western Reserve University-School of Medicine, Cleveland

  Bryan L. Roth

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