Transgenic and Knockout Models of Neuropsychiatric Disorders

  • Gene S. Fisch
  • Jonathan Flint

Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction and Overview

    1. Front Matter
      Pages 1-1
    2. Linda J. Hayes, Diana Delgado
      Pages 45-67
    3. Trevor Humby, Lawrence Wilkinson
      Pages 69-83
  3. Transgenic and Knockout Models of Neurocognitive Dysfunction

    1. Front Matter
      Pages 85-85
    2. Harry T. Orr
      Pages 87-99
    3. Hans Welzl, Patrizia D’Adamo, David P. Wolfer, Hans-Peter Lipp
      Pages 101-125
    4. Thomas Bourgeron, Stéphane Jamain, Sylvie Granon
      Pages 151-174
  4. Transgenic and Knockout Models of Neuropsychiatric Dysfunction

    1. Front Matter
      Pages 175-175
    2. Joseph A. Gogos, Maria Karayiorgou
      Pages 177-191
    3. Stephen I. Deutsch, Katrice Long, Richard B. Rosse, Yousef Tizabi, Ronit Weizman, Judy Eller et al.
      Pages 193-220
    4. Robert Gerlai, Robert Blanchard, Caroline Blanchard
      Pages 221-236
    5. Andrew Holmes, John F. Cryan
      Pages 237-263
    6. Anneloes Dirks, Lucianne Groenink, Berend Olivier
      Pages 265-285
  5. Back Matter
    Pages 287-296

About this book


Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language.
Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today.


depression psychiatry schizophrenia

Editors and affiliations

  • Gene S. Fisch
    • 1
    • 2
  • Jonathan Flint
    • 3
    • 4
  1. 1.Department of StatisticsYeshiva UniversityNew York
  2. 2.Department of PsychologyCUNY/Lehman CollegeNew York
  3. 3.Wellcome Trust Centre for Human GeneticsOxfordUK
  4. 4.Department of PsychiatryUniversity of OxfordOxfordUK

Bibliographic information

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