Principles of Molecular Medicine

  • Marschall S. Runge
  • Cam Patterson

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Genetics

    1. Front Matter
      Pages 1-2
    2. Bruce R. Korf
      Pages 3-8
    3. Shawn E. McCandless, Suzanne B. Cassidy
      Pages 9-18
    4. Christopher I. Amos, John S. Witte, William G. Newman
      Pages 19-26
    5. Sharon E. Plon
      Pages 27-33
    6. Renee E. Edkins, Dennis J. Cheek
      Pages 34-38
    7. Robin L. Bennett
      Pages 46-52
    8. Robert W. Williams
      Pages 53-60
    9. Marcia Van Riper
      Pages 61-65
  3. Cardiology

    1. Front Matter
      Pages 66-68
    2. Lazaros K. Kochilas, Alvin J. Chin
      Pages 69-97
    3. Carolyn Y. Ho, Christine E. Seidman
      Pages 98-104
    4. Clive J. Lewis, Federica Del Monte, Sian E. Harding, Roger J. Hajjar
      Pages 105-115
    5. Saumya Das, James L. Januzzi Jr., Eric M. Isselbacher
      Pages 116-120
    6. Robert E. Gerszten, Anthony Rosenzweig
      Pages 121-129
    7. Mason W. Freeman
      Pages 130-137
    8. Khurshed A. Katki, Donald J. Dipette
      Pages 138-145
    9. Thomas Force, Jeffery D. Molkentin
      Pages 146-156
    10. Barry London
      Pages 157-165
    11. Calum A. Macrae, Christopher J. O’donnell
      Pages 166-174
    12. David A. Dichek
      Pages 175-184
  4. Pulmonary Diseases

    1. Front Matter
      Pages 185-187
    2. Talmadge E. King Jr.
      Pages 188-197
    3. Stephen T. Holgate, Gordon Dent, Mark G. Buckley
      Pages 198-213
    4. Steven D. Shapiro
      Pages 214-222
    5. Brian Fouty, David M. Rodman
      Pages 223-230
    6. Michelle Ng Gong, David C. Christiani
      Pages 231-238
    7. Peadar G. Noone, Maimoona Zariwala, Michael R. Knowles
      Pages 239-250
    8. Scott H. Donaldson, Richard C. Boucher
      Pages 251-258
    9. Eric W.F.W. Alton, Jane C. Davies, Duncan M. Geddes
      Pages 259-268
    10. Kelly D. Chason, Stephen L.
      Pages 269-276
    11. Jeffrey A. Whitsett, Susan E. Wert, Bruce C. Trapnell
      Pages 277-285
  5. Endocrinology

    1. Front Matter
      Pages 286-290
    2. Stephen R. Hammes, Carol A. Lange, Michael J. McPhaul
      Pages 291-307
    3. William L. Lowe Jr.
      Pages 308-318
    4. Shlomo Melmed
      Pages 319-326
    5. John A. III, Amy Potter
      Pages 327-336
    6. Peter Kopp
      Pages 337-356
    7. Andrew Arnold, Michael A. Levine
      Pages 357-364
    8. Robert C. Wilson, Maria I. New
      Pages 365-376
    9. Richard J. Auchus, William E. Rainey, Keith L. Parker
      Pages 377-385
    10. Rajesh V. Thakker
      Pages 386-392
    11. Robert F. Gagel, Sarah Shefelbine, Hironori Hayashi, Gilbert Cote
      Pages 393-399
    12. Charmian A. Quigley
      Pages 400-445
    13. Andrew R. Zinn
      Pages 446-452
    14. Tomonobu Hasegawa
      Pages 453-465
    15. Michael J. McPhaul
      Pages 466-472
    16. Marco Marcelli, Glenn R. Cunningham, José M. Garcia, Kirk C. Lo, Dolores J. Lamb
      Pages 473-494

About this book


Marschall S. Runge, MD, PhD, Cam Patterson, MD, and a panel of 251 authoritative contributors-many of them world-renowned clinicians and researchers-have now updated and expanded the much-acclaimed first edition of Principles of Molecular Medicine to provide an integrated survey of the basic principles of internal medicine in the light of recent dramatic discoveries in molecular medicine and new technologies for the diagnosis and treatment of human disease. This second edition contains new sections on genetics, oncology, metabolic diseases, and infectious diseases, in addition to fully revised sections on neurology, cardiology, hematology, nephrology, endocrinology, dermatology, immunology, gastroenterology, pulmonary disease, musculoskeletal medicine, and psychiatry. Here, the reader will discover the latest findings about direct links between genetic mutations and diseases, genomic approaches to a variety of diseases, and stem cell populations that regenerate muscle, heart, and neural cell populations. Other advances elucidated include the roles of bone morphogenetic proteins in pulmonary hypertension, mutations involved in an array of cardiomyopathies, and new understanding of the biology of previously untreatable neurodegenerative diseases, such as Huntington's disease. For this edition, the authors have also focused on producing a tightly written text with more useful figures and tables and reduced references, so that the text is more immediately useful but not overwhelming as a reference book. A CD-ROM edition of the book (ISBN: 1-58829-929-5) is available separately.
Comprehensive and state-of-the-art, Principles of Molecular Medicine, Second Edition, offers practicing physicians, researchers, and residents an extraordinary summary of the rapidly emerging molecular mechanisms underlying disease and valuable insights into the nature and direction of future developments.


Chromosom Internal medicine Termination gene therapy genes genetics infectious diseases

Editors and affiliations

  • Marschall S. Runge
    • 1
  • Cam Patterson
    • 1
  1. 1.Department of Medicine, Division of Cardiology Carolina Cardiovascular Biology CenterUniversity of North Carolina School of MedicineChapel Hill

Bibliographic information

  • DOI
  • Copyright Information Humana Press Inc. 2006
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-202-5
  • Online ISBN 978-1-59259-963-9
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology