Chemical Genomics

Reviews and Protocols

  • Edward D. Zanders

Part of the Methods in Molecular Biology™ book series (MIMB, volume 310)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Reviews

    1. Front Matter
      Pages 1-1
    2. Paul R. Caron
      Pages 3-10
    3. Lutz Weber
      Pages 11-24
  3. Protocols

    1. Front Matter
      Pages 41-41
    2. Ana Cecília A. Roque, Geeta Gupta, Christopher R. Lowe
      Pages 43-62
    3. Aldo Jongejan, Chris de Graaf, Nico P. E. Vermeulen, Rob Leurs, Iwan J. P. de Esch
      Pages 63-91
    4. Kang Ryu, Steven Lin, Jun Shao, Jing Song, Min Chen, Wei Wang et al.
      Pages 93-105
    5. Sharon A. Doyle
      Pages 107-113
    6. Tatsuya Sawasaki, Mudeppa D. Gouda, Takayasu Kawasaki, Takafumi Tsuboi, Yuzuru Toscana, Kazuyuki Takai et al.
      Pages 131-144
    7. Jan Marik, Kit S. Lam
      Pages 217-226
    8. Judith Webster, David Oxley
      Pages 227-240
    9. Ruobing Wang, Shaoyi Liu, Dhaval Shah, Denong Wang
      Pages 241-252
  4. Back Matter
    Pages 273-279

About this book


Chemical genomics is an exciting new field that promises to transform biological chemistry into a high-throughput industrialized process, much in the same way that genomics has transformed molecular biology. In Chemical Genomics: Reviews and Protocols, leading edge researchers introduce the uninitiated into the various "flavors" of chemical genomics and describe a series of readily reproducible techniques for applications in organic chemistry, protein chemistry, and computer science, with emphasis on the high-throughput approaches that are the essence of chemical genomics. The techniques range from the classic design of small molecules as affinity ligands for specific protein families, to in silico docking for computational approaches, to protein-small molecule interactions, to producing highly diverse collections of proteins, carbohydrates, and small molecules for use in arrays containing large numbers of these molecules. There are also methods for the production of proteins and carbohydrates using different expression systems, for analyzing proteins using mass spectrometry, and for arraying proteins and carbohydrates on solid supports. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and timely, Chemical Genomics: Reviews and Protocols offers researchers an accessible introduction by pioneers to the key areas and methods of chemical genomics, as well as its use in the discovery and evaluation of novel drug targets.


Escherichia coli Microarray Proteomics genetic information molecular biology organic chemistry proteins reproducible techniques

Editors and affiliations

  • Edward D. Zanders
    • 1
  1. 1.CamBP Ltd.CambridgeUK

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2005
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-399-2
  • Online ISBN 978-1-59259-948-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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