Dopamine and Glutamate in Psychiatric Disorders

  • Werner J. Schmidt
  • Maarten E. A. Reith

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Dopamine

    1. Front Matter
      Pages 1-1
    2. Kim A. Neve
      Pages 3-43
    3. Neil M. Richtand, Laurel M. Pritchard, Lique M. Coolen
      Pages 45-61
  3. Glutamate

    1. Front Matter
      Pages 63-63
    2. Yoland Smith
      Pages 65-77
    3. Daniel T. Monaghan, Julia C. A. More, Bihua Feng, David E. Jane
      Pages 79-116
    4. Krystyna Ossowska
      Pages 117-149
  4. Schizophrenia

    1. Front Matter
      Pages 151-151
    2. Bart A. Ellenbroek
      Pages 153-168
    3. Beate D. Kretschmer
      Pages 181-195
  5. Depression

    1. Front Matter
      Pages 197-197
    2. Phil Skolnick
      Pages 199-214
    3. Joaquín Del Río, Diana Frechilla
      Pages 215-234
  6. Stress and Aggression

    1. Front Matter
      Pages 235-235
    2. Klaus A. Miczek, Eric W. Fish
      Pages 237-263
  7. Anxiety

    1. Front Matter
      Pages 265-265
    2. David N. Stephens
      Pages 267-289
  8. Attention Deficit Hyperactivity Disorder

    1. Front Matter
      Pages 291-291
    2. James M. Swanson, Nora D. Volkow, Jeffrey Newcorn, B. J. Casey, Robert Moyzis, David K. Grandy et al.
      Pages 293-315
  9. Addiction

    1. Front Matter
      Pages 317-317
    2. Richard J. Beninger, Todor V. Gerdjikov
      Pages 319-354
    3. David A. Baker, Peter W. Kalivas
      Pages 355-369
    4. Thomas M. Tzschentke
      Pages 371-386
    5. Anton Y. Bespalov, Robert L. Balster
      Pages 387-412
  10. Neurodegeneration

    1. Front Matter
      Pages 413-413
    2. Gabriele Gille, Peter Riederer
      Pages 415-445
    3. Antonello Novelli, Marcos Pérez-Basterrechea, Maria Teresa Fernández-Sánchez
      Pages 447-472
  11. Parkinson’s Disease

    1. Front Matter
      Pages 473-473
    2. Heinz Reichmann, Bernd Janetzky, Peter Riederer
      Pages 503-522
  12. Huntington’s Disease

    1. Front Matter
      Pages 537-537
    2. Carlos Cepeda, Marjorie A. Ariano, Michael S. Levine
      Pages 539-565
  13. Dementias

    1. Front Matter
      Pages 567-567
  14. Back Matter
    Pages 583-600

About this book


Continous rigorous research in basic neurosciences and in clinical studies has enormously increased our knowledge of the neurobiological basis of mental functions and of the neuronal dysfunctions underlying such diseases as schizophrenia, depression, attention deficit disorder, and Parkinson's disease. A transmitter system does not work in isolation, it interacts with other transmitters and the balance between several transmitter determines the outcome, either physiological or pathological. Such a critical balance exists between dopamine and glutamate, which in many brain areas play functionally opposing roles. In Dopamine and Glutamate in Psychiatric Disorders, a panel of neurochemists, pharmacologists, experimental psychologists, and clinicians summarizes our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and from that develops novel therapeutic strategies and possibilities for the future. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, on the origin, progression, and cognitive aspects of Parkinson's disease. Additional chapters offer illuminating insights into a variety of psychiatric diseases, including attention deficit hyperactivity disorder, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques. The authors also offer a critical selection and evaluation of relevant literature and a description of future directions for new therapy development.
Path-breaking and insightful, Dopamine and Glutamate in Psychiatric Disorders offers behavioral pharmacologists, neurobiologists, and clinicians an enlightening review of the neurobiological basis and treatment strategies of today's most important psychiatric and neurological diseases.


Alzheimer Parkinson attention attention deficit hyperactivity disorder (ADHD) biochemistry dementia depression dopamine hyperactivity psychiatric disorder

Editors and affiliations

  • Werner J. Schmidt
    • 1
  • Maarten E. A. Reith
    • 2
  1. 1.Department of Neuropharmacology Zoological InstituteUniversity of TübingenTübingenGermany
  2. 2.Department of PsychiatryNew York University School of MedicineNew York

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2005
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-325-1
  • Online ISBN 978-1-59259-852-6
  • Buy this book on publisher's site
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