© 2004

Epilepsy and the Ketogenic Diet

  • Carl E. Stafstrom
  • Jong M. Rho

Part of the Nutrition and Health book series (NH)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Background

    1. Front Matter
      Pages 1-1
    2. Carl E. Stafstrom
      Pages 3-29
    3. James W. Wheless
      Pages 31-50
  3. Clinical Aspects

    1. Front Matter
      Pages 51-51
    2. Eric H. Kossoff, John M. Freeman
      Pages 53-61
    3. Beth Zupec-Kania, Rhonda Roell Werner, Mary L. Zupanc
      Pages 63-81
    4. Jeri E. Nichols Sutherling, Danine Mele-Hayes
      Pages 83-94
    5. James E. Rubenstein, Eileen P. G. Vining
      Pages 95-102
    6. Michael R. Sperling, Maromi Nei
      Pages 103-109
    7. Anna Gunhild Christina Bergqvist
      Pages 111-121
    8. Karen R. Ballaban-Gil
      Pages 123-128
    9. Carl E. Stafstrom, Gregory L. Holmes
      Pages 161-175
  4. Basic Science Perspectives

    1. Front Matter
      Pages 177-177
    2. Douglas R. Nordli Jr., Darryl C. De Vivo
      Pages 179-184
    3. Marc Yudkoff, Yevgeny Daikhin, Ilana Nissim, Itzhak Nissim
      Pages 185-199
    4. Tim E. Cullingford
      Pages 201-215

About this book


Recent advances in our understanding of the ketogenic diet (KD)-a high-fat, low-carbohydrate, adequate-protein diet used for the treatment of medically intractable epilepsy-have produced a resurgence of interest in, and application of, this valuable treatment for the epileptic patient. In Epilepsy and the Ketogenic Diet, internationally recognized researchers and clinicians from around the world synthesize the current state of the science and clinical practice of the KD. On the basic science side, the authors review what is known about the basic biochemical mechanisms of action of the KD at the molecular level, spelling out in detail its complex interactions with nutrient components, neurodevelopment, brain biochemistry, and physiology. They also examine the effects of the KD on the metabolism of fats, amino acids, and carbohydrates in the central nervous system at both the macro and cellular levels. On the clinical side, physicians, dietitians, and nurses provide a full range of information concerning the treatment of seizures with KD, including a detailed assessment of the indications for, and the contraindications and/or complications that arise from its use, detailed equations that permit the caregiver to calculate the actual amounts of different types of foods that can be included in daily diet plans, and documented information on the carbohydrate and calorie content of hundreds of commonly used drugs. Numerous relevant tables, graphs, and figures, as well as up-to-date references, consistent use of terms across chapters, and a highly annotated index ensure easy access to needed information.
Illuminating and highly practical, Epilepsy and the Ketogenic Diet constitutes a unique benchmark synthesis of up-to-date clinical and scientific information that explains the mechanisms behind the KD and how its maximum therapeutic benefits may be realized in the epileptic patient with minimal adverse effects.


Nervous System Public Health biochemistry carbohydrate chemistry ketones neuropeptides nutrition physiology wein

Editors and affiliations

  • Carl E. Stafstrom
    • 1
  • Jong M. Rho
    • 2
  1. 1.Department of NeurologyUniversity of WisconsinMadisonUSA
  2. 2.The Barrow Neurological InstituteSt. Joseph’s Hospital and Medical CenterPhoenixUSA

Bibliographic information

  • Book Title Epilepsy and the Ketogenic Diet
  • Editors Carl E. Stafstrom
    Jong M. Rho
  • Series Title Nutrition and Health
  • DOI
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-1-58829-295-7
  • Softcover ISBN 978-1-61737-477-7
  • eBook ISBN 978-1-59259-808-3
  • Edition Number 1
  • Number of Pages XX, 355
  • Number of Illustrations 41 b/w illustrations, 0 illustrations in colour
  • Topics Clinical Nutrition
  • Buy this book on publisher's site
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Foreword by Philip A. Schwartzkroin, PhD
"This book is a comprehensive summary of the use of the ketogenic diet for treatment of medically intractable epilepsy. This book should be read by all those caring for patients with medically intractable epilepsy, and should be on the shelves of all those involved in supervising the ketogenic diet."-The Lancet