Handbook of Drug-Nutrient Interactions

  • Joseph I. Boullata
  • Vincent T. Armenti

Part of the Nutrition and Health book series (NH)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Overview of Drug-Nutrient Interactions

    1. Front Matter
      Pages 1-1
    2. Joseph I. Boullata, Jacqueline R. Barber
      Pages 3-25
    3. Robert B. Raffa
      Pages 27-42
    4. Thomas K. H. Chang
      Pages 43-67
    5. Francis E. Rosato Jr.
      Pages 69-80
  3. Influence of Nutritional Status on Drug Disposition and Effect

    1. Front Matter
      Pages 81-81
    2. Charlene W. Compher
      Pages 83-99
    3. Joseph I. Boullata
      Pages 101-126
  4. Influence of Food or Nutrients on Drug Disposition and Effect

    1. Front Matter
      Pages 127-127
    2. David Fleisher, Burgunda V. Sweet, Ameeta Parekh
      Pages 129-154
    3. David G. Bailey
      Pages 175-194
    4. Imad F. Btaiche, Michael D. Kraft
      Pages 195-216
    5. Jeffrey J. Mucksavage, Lingtak-Neander Chan
      Pages 217-233
    6. Mariana Markell
      Pages 235-240
  5. Influence of Pharmaceuticals on Nutritional Status, Nutrient Disposition, and Effect

    1. Front Matter
      Pages 241-241
    2. Jane M. Gervasio
      Pages 243-256
    3. Honesto M. Poblete Jr., Raymond C. Talucci II
      Pages 257-270
    4. Leslie Schechter, Patricia Worthington
      Pages 271-284
    5. Sue A. Shapses, Yvette R. Schlussel, Mariana Cifuentes
      Pages 301-328
  6. Drug-Nutrient Interactions by Life Stage

    1. Front Matter
      Pages 329-329
    2. Deborah A. Maka, Lori Enriquez, Maria R. Mascarenhas
      Pages 331-344
    3. Kathleen L. Hoover, Marcia Silkroski, Leslie Schechter, Patricia Worthington
      Pages 345-361
    4. Tanya C. Knight-Klimas, Joseph I. Boullata
      Pages 363-410
  7. Drug-Nutrient Interactions in Specific Conditions

    1. Front Matter
      Pages 411-411
    2. Matthew J. Weiss, Vincent T. Armenti, Jeanette M. Hasse
      Pages 425-440
    3. Adrianne Bendich, Ronit Zilberboim
      Pages 441-478
    4. Steven P. Gelone, Judith A. O’Donnell
      Pages 479-497
    5. Allison Wood Wallace
      Pages 499-514
  8. Back Matter
    Pages 553-565

About this book


Although drug-nutrient interactions can produce therapeutic failure, adverse drug reactions, and altered nutritional status, many clinicians do not recognize this potential when prescribing drugs or understand that drug-nutrient interactions can be as important as drug-drug interactions. In Handbook of Drug-Nutrient Interactions, well-recognized and respected authorities comprehensively review many of the more common, and some less common, drug-nutrient interactions, detailing the mechanisms and clinical approaches to their effective management. Providing more than a simple listing of common interactions, this much needed work explores, in-depth, every major aspect of the problem, including drug and nutrient disposition, enzyme systems, the effects of nutritional status on drug disposition, and the influence of food, nutrients, and non-nutrient components on drug effects and disposition. The authors present the latest findings on the influence of medications on nutrient status and on those interactions relevant to life-cycle stages and to specific patient groups. Separate chapters examine the effects of caffeine, charcoal broiling, grapefruit juice, alcohol, garlic, ginko biloba, dietary minerals, folate, vitamins D and K, and calcium. Cutting-edge reviews offer detailed information on the major drugs affecting the cardiovascular and nervous systems, with emphasis on the antiepileptics. Extensive tables provide clinical recommendations and organize the data clearly to help the reader evaluate nutrition's critical role in optimizing drug efficacy, especially in at-risk populations. An extensive index and copious up-to-date references ensure rapid access to needed information and key citations.
Comprehensive and clinically oriented, Handbook of Drug-Nutrient Interactions provides health professionals in many areas of research and practice with the most up-to-date, well-referenced, and easy-to-understand survey of nutrition's central importance in optimizing drug efficacy and avoiding adverse effects. It constitutes a benchmark in the field and should be on the desk of every prescribing healthcare professional as a key reference.


Absorption Calcium Malnutrition Nutrition cancer enzymes metabolism

Editors and affiliations

  • Joseph I. Boullata
    • 1
  • Vincent T. Armenti
    • 2
  1. 1.Department of Pharmacy PracticeTemple University School of PharmacyPhiladelphiaUSA
  2. 2.Department of SurgeryTemple University School of MedicinePhiladelphiaUSA

Bibliographic information

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Health & Hospitals
Public Health