Early Clinical Intervention and Prevention in Schizophrenia

  • William S. Stone
  • Stephen V. Faraone
  • Ming T. Tsuang

Table of contents

  1. Front Matter
    Pages i-xiv
  2. The Etiology and Genetics of Schizophrenia

    1. Front Matter
      Pages 1-1
    2. Stephen V. Faraone, Stephen J. Glatt, Levi Taylor
      Pages 3-21
    3. Jason Schiffman, John Carter, Ricardo A. Machón, Sarnoff Mednick
      Pages 23-41
  3. The Vulnerability to Schizophrenia

    1. Front Matter
      Pages 73-73
    2. Jaak Rakfeldt, Thomas H. McGlashan
      Pages 75-91
    3. Stephen V. Faraone, Ming T. Tsuang, Sarah I. Tarbox
      Pages 93-114
    4. Allan F. Mirsky, Connie C. Duncan
      Pages 115-132
    5. Elaine Walker, Karen M. Hochman
      Pages 159-177
    6. Larry J. Seidman, Heidi E. Wencel, Colm McDonald, Robin M. Murray, Ming T. Tsuang
      Pages 179-210
    7. Paola Dazzan, Eugenia Kravariti, Paul Fearon, Robin M. Murray
      Pages 225-252
  4. Early Intervention and Prevention of Schizophrenia

    1. Front Matter
      Pages 253-253
    2. C. Hendricks Brown, Stephen V. Faraone
      Pages 255-283
    3. Ming T. Tsuang, Sarah I. Tarbox, Levi Taylor, William S. Stone
      Pages 285-301
    4. Barbara Cornblatt, Todd Lencz, Christopher Smith, Andrea Auther
      Pages 303-323
    5. Debby W. Tsuang, Stephen V. Faraone, Ming T. Tsuang
      Pages 325-336
  5. Challenges for the Near Future

    1. Front Matter
      Pages 337-366
    2. William S. Stone, Stephen J. Glatt, Stephen V. Faraone
      Pages 339-353
  6. Back Matter
    Pages 367-374

About this book


Although much work remains to be done toward understanding the causes of schizophrenia and attenuating its symptoms, a clear consensus has emerged that better outcomes are associated with early treatment. In Early Clinical Intervention and Prevention in Schizophrenia, leading and internationally recognized researchers review what is known about the liability to schizophrenia, how it progresses, what it looks like clinically-with an emphasis on a specific (proposed) syndrome of liability (schizotaxia)-and how best it might be treated now and in the near future. The authors summarize the latest findings on the genetic, early environmental, and neurodevelopmental origins of schizophrenia, and detail the nature of the vulnerability to schizophrenia from several perspectives, including the prodrome and their proposed pre-prodromal syndrome of schizotaxia. Specific factors, such as cognitive deficits in high-risk populations, neuroanatomical abnormalities, and psychophysiological deficits are also considered. From this material, the contributors develop protocols for the treatment of schizotaxia and prodromal symptoms, and discuss issues related to genetic counseling. They also explore the neurochemical and molecular possibilities for advancing the goals of prevention and early intervention in schizotaxia.
Timely and cutting-edge, Early Clinical Intervention and Prevention in Schizophrenia offers psychologists, psychiatrists, and neurologists an authoritative account of how the liability to develop schizophrenia is expressed in meaningful, measurable ways that can provide a basis for early intervention and preventive efforts.


Syndrom emotion genetics intervention neurobiology

Editors and affiliations

  • William S. Stone
    • 1
    • 2
  • Stephen V. Faraone
    • 1
    • 3
  • Ming T. Tsuang
    • 1
    • 4
    • 5
  1. 1.Harvard Institute of Psychiatric Epidemiology and GeneticsBostonUSA
  2. 2.Harvard Medical School Department of Psychiatry at Massachusetts Mental Health CenterBostonUSA
  3. 3.Harvard Medical School Department of Psychiatry at Massachusetts General HospitalBostonUSA
  4. 4.Harvard Medical School Departments of Psychiatry at Massachusetts Mental Health Center and Massachusetts General HospitalBostonUSA
  5. 5.Department of EpidemiologyHarvard School of Public HealthBostonUSA

Bibliographic information

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