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Hormones and the Heart in Health and Disease

  • Leonard Share

Part of the Contemporary Endocrinology book series (COE, volume 21)

Table of contents

  1. Front Matter
    Pages i-x
  2. David G. Gardner, Branka Kovacic-Milivojevic, Faquan Liang, Songcang Chen
    Pages 1-20
  3. Willis K. Samson
    Pages 21-38
  4. David G. Parkes, Clive N. May
    Pages 39-52
  5. Haralambos Gavras, Irene Gavras
    Pages 53-67
  6. Celso E. Gomez-Sanchez
    Pages 69-79
  7. Matthew N. Levy
    Pages 81-101
  8. Vernon S. Bishop, Max G. Sanderford
    Pages 103-113
  9. Roger W Brownsey, Brian Rodrigues, Subodh Verma, John H. McNeill
    Pages 115-135
  10. Oscar A. Carretero
    Pages 137-158
  11. David P. Brooks, Eliot H. Ohlstein
    Pages 159-174
  12. Robert D. Bernstein, Fabio A. Recchia, Gabor Kaley, Thomas H. Hintze
    Pages 175-193
  13. Kafait U. Malik
    Pages 195-218
  14. Jay M. Sullivan
    Pages 219-233
  15. Carrie J. Bagatell, William J. Bremner
    Pages 235-251
  16. Back Matter
    Pages 253-258

About this book

Introduction

The maintenance of arterial blood pressure and the distribution of blood flow to the various organs of the body depends on the control of the pumping action of the heart and of the resistance of the vascular beds in the individual organs in accordance with their metabolic needs. These controls are achieved through the integrated actions of circulat­ ing hormones, humoral factors that are synthesized and released in the heart and blood vessels, and the autonomic nervous system. The heart, however, is not only the target for the direct and indirect actions of a number of hormones and humoral factors, it is also an endocrine organ in the traditional sense, synthesizing and secreting into the circulation chemical factors that act at distant sites. In this treatise, Hormones and the Heart in Health and Disease, we interpret "endocrinology" broadly and consider traditional hormones as well as autocoids that are secreted by the heart or that act on it. In this overview, the relevant chapters are indicated in parentheses. The discovery of atrial natriuretic peptide (ANP; atrial natriuretic factor, ANF) in the 1980s indicated that the heart does indeed function as an endocrine organ in the classic sense. ANP (Chapter I) is synthesized in the heart and secreted into the circulation for actions on the kidney, where it is a potent natriuretic agent, and on the vasculature, where it causes vasodilation. ANP can also affect myocardial contractility.

Keywords

aldosterone blood vessel cardiovascular endothelium insulin pathophysiology physiology

Editors and affiliations

  • Leonard Share
    • 1
  1. 1.Department of PhysiologyThe University of TennesseeMemphisUSA

Bibliographic information

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