© 2000

Mitochondrial Inhibitors and Neurodegenerative Disorders

  • Paul R. Sanberg
  • Hitoo Nishino
  • Cesario V. Borlongan

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Mitochondrial Toxins

    1. Front Matter
      Pages 1-1
    2. Mohammad I. Sabri, Peter S. Spencer, Safia Baggia, Albert C. Ludolph
      Pages 3-19
    3. Bradley F. Hamilton, Daniel H. Gould, David L. Gustine
      Pages 21-33
    4. Norman C. Reynolds Jr., Wen Lin
      Pages 35-49
  3. Mitochondrial Dysfunctions

    1. Front Matter
      Pages 51-51
    2. Gail D. Zeevalk
      Pages 53-72
    3. Gary L. Dunbar, Deborah A. Shear, Jie Dong, Kristi L. Haik-Creguer
      Pages 73-92
    4. Cesario V. Borlongan, Toru Shimizu, Paul R. Sanberg
      Pages 93-106
    5. James W. Geddes, Vimala Bondada, Zhen Pang
      Pages 107-120
    6. Keiya Nakajima, Yasunobu Shimano, Kunio Torii, Hitoo Nishino
      Pages 121-127
    7. Tajrena Alexi, Richard L. M. Faull, Paul E. Hughes
      Pages 129-140
    8. Keith J. Page, Alicia Meldrum, Stephen B. Dunnett
      Pages 141-156
    9. Michiko Kumazaki, Chucharin Ungsuparkorn, Shripad B. Deshpande, Atsuo Fukuda, Hitoo Nishino
      Pages 157-165
    10. Alicia Meldrum, Keith J. Page, Barry J. Everitt, Stephen B. Dunnett
      Pages 201-217
    11. Terence J. Bazzett, Roger L. Albin, Jill B. Becker
      Pages 219-231
    12. Yun Wang, Cesario V. Borlongan
      Pages 233-242
  4. Treatment Interventions for Mitochondrial-Induced Neurotoxicity

    1. Front Matter
      Pages 243-243

About this book


In Mitochondrial Inhibitors and Neurodegenerative Disorders, respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers-many pioneers in the field-detail the symptomatology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The book focuses on 3-nitropropionic acid (3-NP) and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease, and demonstrates that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. In addition, recent therapeutic modalities aimed at rescuing the central nervous system from abnormal functioning by mitochondria are discussed.
With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression.


Nervous System Parkinson brain central nervous system chemistry death dopamine hypoxia metabolism mitochondria neurochemistry neurodegenerative disorders protein

Editors and affiliations

  • Paul R. Sanberg
    • 1
  • Hitoo Nishino
    • 2
  • Cesario V. Borlongan
    • 3
  1. 1.Department of Neurosurgery, and Program in NeuroscienceUniversity of South Florida College of MedicineTampaUSA
  2. 2.Department of PhysiologyNagoya City University Medical SchoolMizuho-cho, Mizuho-ku, NagoyaJapan
  3. 3.Cellular Neurophysiology, Intramural Research Program, National Institute on Drug AbuseNational Institutes of HealthBaltimoreUSA

Bibliographic information

  • Book Title Mitochondrial Inhibitors and Neurodegenerative Disorders
  • Editors Paul R. Sanberg
    Hitoo Nishino
    Cesario V. Borlongan
  • Series Title Contemporary Neuroscience
  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-805-9
  • Softcover ISBN 978-1-4684-9821-9
  • eBook ISBN 978-1-59259-692-8
  • Edition Number 1
  • Number of Pages XVIII, 314
  • Number of Illustrations 81 b/w illustrations, 0 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site
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" a concise summary of the present state of research in the area of mitochondrial toxins and their role in animal models of neurodegenerative disease."-J Neuropsychiatry Clin Neurosci