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Neural Transplantation Methods

  • Stephen B. Dunnett
  • Alan A. Boulton
  • Glen B. Baker

Part of the Neuromethods book series (NM, volume 36)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Sources of Cells for Transplantation

    1. Front Matter
      Pages 1-1
    2. Stephen B. Dunnett, Anders Björklund
      Pages 3-25
    3. Siddharthan Chandran, Clive N. Svendsen
      Pages 41-54
    4. Vincent M. Mann, John D. Sinden
      Pages 55-72
    5. Alison E. Willing, Paul R. Sanberg
      Pages 73-88
    6. Cecilia Lundberg
      Pages 89-102
    7. Ronald J. Mandel, Steve Hardy, Richard O. Snyder, Luigi Naldini, Stuart E. Leff
      Pages 103-130
  3. Methods of Implantation

    1. Front Matter
      Pages 131-131
    2. Stephen B. Dunnett, Anders Björklund
      Pages 133-148
    3. Ingrid Strömberg
      Pages 149-167
    4. Anthony J. Castro, Jens Zimmer
      Pages 169-194
    5. Roger A. Barker, Anne E. Rosser, Stephen B. Dunnett
      Pages 195-205
    6. Guido Nikkhah, Christian Winkler, Alexandra Rödter, Madjid Samii
      Pages 207-231
    7. Dwaine F. Emerich, Shelley R. Winn
      Pages 233-277
    8. Robin J. M. Franklin, William F. Blakemore
      Pages 305-317
    9. Alan R. Harvey
      Pages 319-361
  4. Factors in Graft Survival and Function

    1. Front Matter
      Pages 363-363
    2. Ann-Charlotte Granholm
      Pages 385-409
    3. Patrik Brundin, Gabriele S. Kaminski Schierle
      Pages 411-440
    4. James W. Fawcett
      Pages 441-460
    5. Yoshinori Ohmoto, Kathryn Wood
      Pages 461-476
    6. Colin Watts, Stephen B. Dunnett
      Pages 477-501
    7. Walter C. Low, Wei-Ming Duan, C. Dirk Keene, Hsiao-Tzu Ni, Marcus A. Westerman
      Pages 503-541
  5. Back Matter
    Pages 543-556

About this book

Introduction

In Neural Transplantation Methods, leading experimental neurobiologists and neurosurgeons provide all the technical and practical information required to perform neural transplantation in experimental and neurological research, including a detailed consideration of the issues involved in designing and customizing such methods for specific research purposes. The authors outline the different sources of donor tissues and other materials for implantation, and discuss the practicalities of embryonic staging and dissection, of the storage of cells by hibernation or cryopreservation, of the expansion of precursor cells, and of the genetic manipulation of cells for in vivo or ex vivo gene transfer. Tissue implantation techniques used for experimental animals of different species include: in oculo and demyelination models, microtransplantation of cell suspensions, encapsulation of transplanted cells, implantation into immature animals-especially primates-and labeling transplanted cells for subsequent detection. Special attention is given to the factors determining transplant survival and integration, detailing the role of the blood-brain barrier, the importance of vascularization for proper graft nutrition, the role of trophic factors, and strategies for immune suppression.
Neural Transplantation Methods constitutes the single most comprehensive sourcebook of practical information on the effective use of transplantation techniques in experimental neurobiology. Its powerful and flexible techniques will significantly aid all those now working to develop today's powerful new treatments of brain and spinal cord diseases and injuries.

Editors and affiliations

  • Stephen B. Dunnett
    • 1
    • 2
  • Alan A. Boulton
    • 3
  • Glen B. Baker
    • 4
  1. 1.University of CambridgeCambridgeUK
  2. 2.Cardiff UniversityCardiffUK
  3. 3.University of SaskatchewanSaskatoonCanada
  4. 4.University of AlbertaEdmontonCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-690-4
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-793-9
  • Online ISBN 978-1-59259-690-4
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site
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