Advertisement

© 2004

Molecular Neuropharmacology

Strategies and Methods

  • Arne Schousboe
  • Hans Bräuner-Osborne
Book

Table of contents

  1. Front Matter
    Pages i-xi
  2. Molecular Pharmacology of Glutamate Receptors

    1. Front Matter
      Pages 1-1
    2. Sari E. Lauri, Vernon R. J. Clarke, Graham L. Collingridge
      Pages 27-46
  3. Molecular Pharmacology of GABA Receptors

    1. Front Matter
      Pages 83-83
    2. Bjarke Ebert, Sally Anne Thompson, Signe Í. Stórustovu, Keith A. Wafford
      Pages 85-94
    3. Bente Frølund, Anne T. Jørgensen, Tommy Liljefors, Martin Mortensen, Povl Krogsgaard-Larsen
      Pages 113-127
    4. Bernhard Bettler, Hans Bräuner-Osborne
      Pages 129-144
  4. Molecular Pharmacology of Transmitter Transporters

    1. Front Matter
      Pages 145-145
    2. Robert J. Vandenberg, Renae M. Ryan
      Pages 161-174
    3. Alan Sarup, Orla Miller Larsson, Arne Schousboe
      Pages 175-190
    4. Naomi R. Goldberg, Thijs Beuming, Harel Weinstein, Jonathan A. Javitch
      Pages 213-234
    5. Marta Filizola, Irache Visiers, Lucy Skrabanek, Fabien Campagne, Harel Weinstein
      Pages 235-266
  5. Back Matter
    Pages 267-271

About this book

Introduction

The ability to clone large numbers of receptors and transporters for neurotransmitters, and then to produce specific mutations of these proteins, has yielded significant understanding of their pharmacological and functional properties, with still deeper insight obtainable through the application of computational and medicinal chemistry. In Molecular Neuropharmacology: Strategies and Methods, leading neuroscience investigators combine advanced chemistry with molecular modeling to produce a powerful collection of cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. Information about x-ray crystallographic analyses is included whenever available.
State-of-the-art and highly practical, Molecular Neuropharmacology: Strategies and Methods provides detailed accounts of the tools needed to understand how CNS neurons communicate and promises the development of novel therapeutic agents and strategies for many neurological diseases.

Keywords

GABA cloning cognition lead neurons neuropharmacology neurotransmitter protein research

Editors and affiliations

  • Arne Schousboe
    • 1
  • Hans Bräuner-Osborne
    • 2
  1. 1.Department of PharmacologyThe Danish University of Pharmaceutical SciencesCopenhagenDenmark
  2. 2.Department of Medical ChemistryThe Danish University of Pharmaceutical SciencesCopenhagenDenmark

Bibliographic information

  • Book Title Molecular Neuropharmacology
  • Book Subtitle Strategies and Methods
  • Editors Arne Schousboe
    Hans Bräuner-Osborne
  • DOI https://doi.org/10.1007/978-1-59259-672-0
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-1-58829-143-1
  • Softcover ISBN 978-1-61737-384-8
  • eBook ISBN 978-1-59259-672-0
  • Edition Number 1
  • Number of Pages XI, 271
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Psychopharmacology
    Neurology
    Molecular Medicine
    Neurosciences
  • Buy this book on publisher's site
Industry Sectors
Pharma

Reviews

"I would highly recommend this book to neuroscientists, pharmacologists, and medicinal chemists who are interested in ligand-macromolecular interactions. It provides descriptions of state-of-the-art tools needed to understand how CNS neurons communicate and perspectives regarding the development of novel therapeutic drugs for neurological diseases. Each chapter is well written and concise beginning with an appropriate introduction to the topic and ending with a brief summary, conclusion, or future perspective section. The references are selective and appropriate. Special features include cutting-edge techniques for using site directed mutagenesis and molecular modeling; novel insights into the functioning of transmitter receptors and transporters; and state-of-the-art discussions on the molecular pharmacology of GABA and glutamate receptors and transmitter transporters. "-Doody's Health Sciences Book Review Journal

"...provides a highly readable account...an excellent book." - ChemBioChem