Gene Therapy for Neurological Disorders and Brain Tumors

  • E. Antonio Chiocca
  • Xandra O. Breakefield

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Vectors and Promoters

    1. Front Matter
      Pages 1-6
    2. Steven A. Reeves
      Pages 7-38
    3. Susanna Chiocca, Matt Cotten
      Pages 39-52
    4. Paul A. Johnson
      Pages 53-62
    5. Cornel Fraefel, Xandra O. Breakefield, David R. Jacoby
      Pages 63-82
    6. Frances I. Smith, Thomas J. McCown
      Pages 83-92
    7. Jean-Michel H. Vos, Keith B. Quattrocchi, Brian J. Wendelburg
      Pages 93-112
    8. Didier Trono, Ulrike Blömer, Luigi Naldini
      Pages 113-120
    9. Jason G. Smith, Stephen L. Eck
      Pages 147-157
  3. Neuro-Oncology

    1. Front Matter
      Pages 159-159
    2. Stephen B. Tatter, Griffith R. Harsh IV
      Pages 161-189
    3. Candelaria Gomez-Manzano, Juan Fueyo, Athanassios P. Kyritsis, W. K. Alfred Yung
      Pages 205-229
    4. John H. Sampson, Darell D. Bigner, Glenn Dranoff
      Pages 231-294
    5. Leslie L. Muldoon, Robert A. Kroll, Michael A. Pagel, Simon Roman-Goldstein, Edward A. Neuwelt
      Pages 295-312
  4. Neurological Diseases

    1. Front Matter
      Pages 339-343
    2. Marie-Claude Senut, Isabelle Aubert, Philip J. Horner, Fred H. Gage
      Pages 345-375
    3. Martha C. Bohn, Derek L. Choi-Lundberg
      Pages 377-395
    4. Peter A. Pechan, Masazumi Fujii, Cornel Fraefel, Andreas Jacobs, Michael A. Moskowitz
      Pages 397-408
    5. Edward M. Kaye
      Pages 409-418
    6. Gudarz Davar
      Pages 419-426
    7. Ole Isacson, Nadia Haque
      Pages 427-443
  5. Back Matter
    Pages 445-458

About this book


Drs. Chiocca and Breakefield bring together in Gene Therapy for Neurological Disorders and Brain Tumors many of the leading gene therapy researchers and clinicians to capture the breadth of the field-from basic vector technology to current and future clinical applications. The authoritative contributions provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorders, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea.

Gene Therapy for Neurological Disorders and Brain Tumors illuminates the rapidly developing applications of gene transfer technologies to the treatment of a wide range of neurological disorders and brain tumors. Readers will learn the current delivery methods for transgenes, will learn the characteristics of the transgene delivery vectors, and come to more fully understand gene therapies for both neuro-oncologic and neurologic disorders.


Bur Nervous System Neurology Parkinson Promoter genes neurons surgery

Editors and affiliations

  • E. Antonio Chiocca
    • 1
  • Xandra O. Breakefield
    • 2
  1. 1.Molecular Neuro-Oncology, Neurosurgical Service, Massachussetts General HospitalHarvard Medical SchoolBostonUSA
  2. 2.Neurogenetics Unit, Massachussetts General HospitalHarvard Medical CenterBostonUSA

Bibliographic information

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