Neuroprotective Signal Transduction

  • Mark P. Mattson

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-x
  2. Elliott J. Mufson, J. H. Kordower
    Pages 23-59
  3. Steve Estus
    Pages 83-94
  4. Atsumi Nitta, Shoei Furukawa, Toshitaka Nabeshima
    Pages 95-110
  5. Kerstin Krieglstein, Josef Krieglstein
    Pages 119-144
  6. Wayne A. Cass, Cecilia M. Kearns, Don M. Gash
    Pages 145-161
  7. Steven W. Barger
    Pages 163-183
  8. David Martin, Gerald Miller, Norman Fischer
    Pages 185-195
  9. Katsutoshi Furukawa
    Pages 197-220
  10. Virginia L. Smith-Swintosky
    Pages 243-258
  11. Back Matter
    Pages 337-347

About this book


In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals.

Neuroprotective Signal Transduction presents fundamental, cutting-edge treatment of the cellular and molecular signal transduction pathways found in human neurodegenerative conditions. The book's elucidation of the molecular cascades evolved by the nervous system to protect itself is now lead to effective strategies for preventing neuronal degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, and will form the basis for powerful new drug discovery and gene therapy strategies.


Deprivation Nervous System Parkinson cellular mechanisms forebrain genes molecular mechanisms neurons proteins signal transduction

Editors and affiliations

  • Mark P. Mattson
    • 1
  1. 1.University of KentuckyLexingtonUSA

Bibliographic information

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