Molecular Mechanisms of Dementia

  • Wilma Wasco
  • Rudolph E. Tanzi

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Andréa LeBlanc
    Pages 57-71
  3. Carl W. Cotman, David H. Cribbs, Aileen J. Anderson
    Pages 73-90
  4. Mark P. Mattson, Katsutoshi Furukawa, Annadora J. Bruce, Robert J. Mark, Emmanuelle Blanc
    Pages 103-143
  5. D. Allan Butterfield, Kenneth Hensley, Nathan Hall, Ramachandran Subramaniam, Beverly J. Howard, Pamela Cole et al.
    Pages 145-167
  6. W. Sue T. Griffin, Jin G. Sheng, Robert E. Mrak
    Pages 169-176
  7. Joseph Rogers, Stephen O’Barr
    Pages 177-198
  8. Michel Goedert, John Q. Trojanowski, Virginia M.-Y. Lee
    Pages 199-218
  9. Craig S. Atwood, Robert D. Moir, Xudong Huang, Rudolph E. Tanzi, Ashley I. Bush
    Pages 225-237
  10. René Etcheberrigaray, Daniel L. Alkon
    Pages 239-252
  11. Jean Paul G. Vonsattel, Giuliano Binetti, Lynne M. Kelley
    Pages 253-269
  12. Raymond T. F. Cheung, Vladimir Hachinski
    Pages 271-291
  13. Piero Parchi, Pierluigi Gambetti
    Pages 293-306
  14. Back Matter
    Pages 307-312

About this book


Wilma Wasco and Rudolph Tanzi bring together in Molecular Mechanisms of Dementia the best and latest thinking by leading scientists on the etiologic and pathogenic events responsible for the onset of Alzheimer's disease and related dementias. In presenting the various mechanisms and multifaceted approaches currently being employed, the distinguished contributors review such critical factors as apoptosis, energy metabolism, excitotoxicity and calcium-mediated cell death, free radicals, electrophysiological abnormalities, environmental toxins, degeneration of neural networks, and modification of the cytoskeleton. They also examine mechanisms by which ischemia and hypoxia result in dementia.

Molecular Mechanisms of Dementia is the first major contemporary review of this dramatically advancing field. It provides an invaluable summary of the tremendous progress that has been made in developing testable models of the molecular mechanisms of dementia, as well as critical insights into the necessary direction of future investigations of dementia. The book is certain to become a standard reference for all researchers now working in the field of neurodegenerative disorders.


Alzheimer dementia genes inflammation molecular mechanisms pathophysiology thinking

Editors and affiliations

  • Wilma Wasco
    • 1
  • Rudolph E. Tanzi
    • 1
  1. 1.Genetics and Aging Unit, Department of NeurologyMassachusetts General Hospital, Harvard Medical SchoolCharlestownUSA

Bibliographic information

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