© 2003

Aging, Immunity, and Infection


Part of the Infectious Disease book series (ID)

Table of contents

  1. Front Matter
    Pages i-x
  2. Joseph F. Albright, Julia W. Albright
    Pages 1-17
  3. Joseph F. Albright, Julia W. Albright
    Pages 19-59
  4. Joseph F. Albright, Julia W. Albright
    Pages 61-134
  5. Joseph F. Albright, Julia W. Albright
    Pages 135-211
  6. Joseph F. Albright, Julia W. Albright
    Pages 213-224
  7. Joseph F. Albright, Julia W. Albright
    Pages 225-232
  8. Back Matter
    Pages 233-241

About this book


With a growing world population of the aged in a state of immunological decline, there is an urgent need to develop new methods to delay or, better yet, prevent the loss of immune function. In Aging, Immunity, and Infection, the prominent immunogerontologists Joseph and Julia Albright, critically review the major features and functions of the immune system that are most likely, or known, to be significantly altered by aging, and offer insightful analyses of the consequences for those aging subjects who must cope with infection. Topics of special interest include the demographics and theories of immunosenescence, the gradual breakdown of resistance to infection in the aged, and the effects of aging on selected mechanisms of both innate and adaptive immunity to infections. The Albrights also suggest how advances may be made in understanding the basic biology of immunosenescence, newer methods of treatment and prevention, and offer an evaluation of such provocative ideas as nutritional intervention and lifespan extension in immunosenescence. Chapter summaries-along with lists of key research areas and recent advances-provide a framework for greater insight into major aspects of the problem and its emerging solutions.
Informative and forward-looking, Aging, Immunity, and Infection offers geriatricians, infectious disease specialists, and immunologists a state-of-the-art understanding of the deleterious effects of aging on the immune system, even as it provides a basis for research on how best to strengthen immunity in the elderly and reduce their susceptibility to infectious diseases.


Thymus antibiotics bacteria bacterial infection bacterial infections fungal infection infection infections infectious infectious disease infectious diseases viral infection

Authors and affiliations

  1. 1.George Washington University School of MedicineUSA

Bibliographic information

  • Book Title Aging, Immunity, and Infection
  • Authors Joseph F. Albright
    Julia W. Albright
  • Series Title Infectious Disease
  • DOI
  • Copyright Information Springer Science+Business Media New York 2003
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-644-4
  • Softcover ISBN 978-1-4684-9787-8
  • eBook ISBN 978-1-59259-402-3
  • Edition Number 1
  • Number of Pages X, 242
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Internal Medicine
    Infectious Diseases
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


"This is a forward-looking book. The two authors provide their synthesis of a very broad and dense field in most interesting ways. Their writing is elegant and annotated. That they can interpolate research and comments made 20 years ago into what is being discovered today is a manifestation of their excellent mastery of the area. They bring it all together in the last chapter by describing what they think would be interesting areas of research in the future. The comments about how caloric restriction may work in the body's resistance to infectious diseases, and the relationship of the gut to overall immune function are profound and insightful. How refreshing it is to see a really good example of scientific writing and thinking." -Doody's Health Sciences Book Review Journal

"This book thoroughly reviews bacterial and viral infections, the innate and adaptive immune responses that occur in infection, and the effect of age on infection. This book is also a good review of host-pathogen interactions, even for those not interested in age-related defects in immune function." -American College of Physicians